1-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propane

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 1-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propane
• 英文别名: 1-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]propane
• 化学式: C9H19N3O3
• 分子量: 217.27
• InChiKey: YNUQUNAEHDMCNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  42
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• CARBOHYDRATE-GLYCOLIPID CONJUGATE VACCINES
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：US20150238597A1

  公开（公告）日：2015-08-27

  The present invention relates to the field of synthesizing and biologically evaluating of a novel class of carbohydrate-based vaccines. The new vaccines consist of a multi-modular structure which allows applying the vaccine to a whole variety of pathogenes. This method allows preparing vaccines against all pathogens expressing immunogenic carbohydrate antigens. As conjugation of antigenic carbohydrates to proteins is not required the conjugate vaccine is particularly heat stable. No refrigeration is required, a major drawback of protein-based vaccines.

  本发明涉及合成和生物评价一种新型基于碳水化合物的疫苗的领域。这种新疫苗由多模块结构组成，可以将疫苗应用于各种病原体。该方法允许制备针对所有表达免疫原碳水化合物抗原的病原体的疫苗。由于不需要将抗原碳水化合物与蛋白质结合，所以结合疫苗尤其耐热稳定。无需冷藏，这是基于蛋白质的疫苗的一个主要缺点。
• ACTIVITY-BASED PROBES FOR THE UROKINASE PLASMINOGEN ACTIVATOR
  申请人：Augustyns Koen

  公开号：US20140079632A1

  公开（公告）日：2014-03-20

  The present invention relates to selective trypsine-like serine protease activity-based probes, in particular urokinase plasminogen activator-activity based probes, the use thereof and methods for detecting selective urokinase activity by making use of said probes.

  本发明涉及选择性胰蛋白酶样丝氨酸蛋白酶活性探针，特别是以尿激酶纤溶酶原激活剂活性为基础的探针，其使用和利用该探针检测选择性尿激酶活性的方法。
• Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same
  申请人：Yale University

  公开号：US20140302523A1

  公开（公告）日：2014-10-09

  The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of a compound to the transmembrane or intracellular protein induces proteasomal degradation of the transmembrane or intracellular protein. The present invention further includes a method of inducing proteasomal degradation of a transmembrane or intracellular protein. The present invention further includes a method of identifying or validating a protein of interest as a therapeutic target for treatment of a disease state or condition.

  本发明包括一些化合物，这些化合物有助于扰乱或破坏跨膜或胞内蛋白的功能，其中化合物与跨膜或胞内蛋白的结合诱导跨膜或胞内蛋白的蛋白酶体降解。本发明还包括一种诱导跨膜或胞内蛋白的蛋白酶体降解的方法。本发明还包括一种鉴定或验证感兴趣蛋白作为治疗疾病状态或病情的治疗靶点的方法。
• TYROSINE BASED LINKERS FOR THE RELEASABLE CONNECTION OF PEPTIDES
  申请人：Bayer Intellectual Property GmbH

  公开号：US20150051160A1

  公开（公告）日：2015-02-19

  The invention relates to novel tyrosine based linkers that allow the releasable connection of peptides or proteins with other molecular entities, e.g. polyethylene glycol, to processes for their preparation and their use for preparing medicaments for the treatment and/or prophylaxis of diseases.

  本发明涉及一种新型基于酪氨酸的连接剂，可以使肽或蛋白质与其他分子实体（例如聚乙二醇）可释放地连接，以及其制备过程和用于制备治疗和/或预防疾病药物的用途。
• POLYNUCLEOTIDE CONSTRUCTS HAVING DISULFIDE GROUPS
  申请人：BRADSHAW Curt W.

  公开号：US20160257961A1

  公开（公告）日：2016-09-08

  The invention features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components is attached to an internucleotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains one or more bulky groups proximal to the disulfide group. The invention also features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components (i) is attached to an internucleotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains at least 4 atoms in a chain between the disulfide linkage and the phosphorus atom of the internucleotide bridging group or the terminal group; and where the chain does not contain a phosphate, an amide, an ester, or an alkenylene. The invention also features methods of delivering a polynucleotide to a cell using the polynucleotide constructs of the invention.

  本发明涉及一种聚核苷酸构建物，其包含一个或多个组分（i），该组分包含一个二硫键，其中每个组分中的一个或多个组分连接到聚核苷酸构建物的核苷酸桥接基团或末端基团上，并且每个组分（i）在二硫键附近包含一个或多个笨重基团。本发明还涉及一种聚核苷酸构建物，其包含一个或多个组分（i），该组分包含一个二硫键，其中每个组分中的一个或多个组分连接到聚核苷酸构建物的核苷酸桥接基团或末端基团上，并且每个组分（i）在二硫键和核苷酸桥接基团或末端基团的磷原子之间的链中至少含有4个原子；并且链中不含有磷酸盐、酰胺、酯或烯基烃。本发明还涉及使用本发明的聚核苷酸构建物向细胞传递聚核苷酸的方法。