(2E,3E)-2-(2-ethoxyethylidene)-3-ethylidene-5-(4-hydroxyphenyl)pyran-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: (2E,3E)-2-(2-ethoxyethylidene)-3-ethylidene-5-(4-hydroxyphenyl)pyran-4-one
• 化学式: C₁₇H₁₈O₄
• 分子量: 286.32
• InChiKey: VZGWGFYAJFNAAB-ZFDMWBGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHODS AND COMPOSITIONS FOR ALTERING HEALTH, WELLBEING, AND LIFESPAN
  申请人：LifeSpan Extension, LLC

  公开号：US20140079836A1

  公开（公告）日：2014-03-20

  Described herein are the results of comprehensive genetic expression and other molecular analysis of the effect of antioxidants on biological systems, including specifically different human cells. Based on these analyses, methods and compositions are described for modifying or influencing the lifespan of cells, tissues, organs, and organisms. In various embodiments, there are provided methods for modulating the activity of the gene maintenance process in order to influence the length and/or structural integrity of the telomere in living cells, as well as methods for modulating the rate/efficiency of the cellular respiration provided by the mitochondria, mitochondrial biogenesis, and maintenance of the mitochondrial membrane potential. Exemplary lifespan altering compounds include natural and synthetic antioxidants, such as plant antioxidant and polyphenol compounds derived from coffee cherry, tea, berry, and so forth, including but not limited to caffeic acid, chlorogenic acid, ferulic acid, quinic acid, proanthocyanidins, ubiquinone, idebenone, or a synthetic form or derivatives thereof.

  本文描述了对抗氧化剂对生物系统的影响进行全面的基因表达和其他分子分析的结果，包括不同的人类细胞。基于这些分析，描述了修改或影响细胞、组织、器官和生物体寿命的方法和组成。在各种实施例中，提供了调节基因维护过程活性的方法，以影响活细胞的端粒长度和/或结构完整性，以及调节线粒体提供的细胞呼吸速率/效率、线粒体生物合成和线粒体膜电位维护的方法。示例寿命改变化合物包括天然和合成抗氧化剂，如来源于咖啡樱桃、茶、浆果等的植物抗氧化剂和多酚化合物，包括但不限于咖啡酸、绿原酸、香草酸、奎尼酸、原花青素、辅酶Q10、依地酚酮或其合成形式或衍生物。