7-methyl-4a,6,7,7a-tetrahydro-4H-furo[3,2-b][1,4]oxazin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 7-methyl-4a,6,7,7a-tetrahydro-4H-furo[3,2-b][1,4]oxazin-3-one
• 化学式: C₇H₁₁NO₃
• 分子量: 157.17
• InChiKey: PCOYBNCBOUMNPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• NOVEL BENZIMIDAZOLE HEXAHYDROFURO[3,2-B]FURAN DERIVATIVES
  申请人：Merck Sharp & Dohme Avenue

  公开号：US20150218183A1

  公开（公告）日：2015-08-06

  The novel benzimidazole hexahydrofuro[3,2-B]furan derivatives of the present invention are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.

  本发明的新型苯并咪唑六氢呋喃[3,2-B]呋喃衍生物是AMP-蛋白激酶的激动剂，并可用于治疗、预防和抑制由AMPK激活的蛋白激酶介导的疾病。本发明的化合物可用于治疗2型糖尿病、高血糖、代谢综合征、肥胖症、高胆固醇血症和高血压。
• US9556193B2
  申请人：——

  公开号：US9556193B2

  公开（公告）日：2017-01-31
• [EN] NOVEL AZABENZIMIDAZOLE HEXAHYDROFURO[3,2-B]FURAN DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS D'AZABENZIMIDAZOLE HEXAHYDROFURO[3,2-B]FURANE
  申请人：MERCK SHARP & DOHME

  公开号：WO2014031515A1

  公开（公告）日：2014-02-27

  Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.