(4R)-2-(2,3-dimethoxyphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (4R)-2-(2,3-dimethoxyphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid
• 化学式: C₁₂H₁₃NO₄S
• 分子量: 267.3
• InChiKey: YTKCIPFRCXWQCS-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  93.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• CELL DIFFERENTIATION INDUCER AND DIFFERENTIATION INDUCING METHOD
  申请人：The University of Tokushima

  公开号：EP2711419A1

  公开（公告）日：2014-03-26

  The objective of the present invention is to provide a cell differentiation inducer which is a low-molecular compound, which can be chemically synthesized easily and which can efficiently induce a differentiation of an undifferentiated cell into a nervous system cell with high selectivity. In addition, the objective of the present invention is to provide use of a specific catechol derivative for efficiently inducing a differentiation of an undifferentiated cell into a nervous system cell with high selectivity, and a method for efficiently inducing a differentiation of an undifferentiated cell into a nervous system cell with high selectivity using a specific catechol derivative. The cell differentiation inducer of the present invention is characterized in comprising the catechol derivative having the specific chemical structure.

  本发明的目的是提供一种细胞分化诱导剂，它是一种低分子化合物，可以很容易地进行化学合成，并能以高选择性有效地诱导未分化细胞分化为神经系统细胞。此外，本发明的目的还在于提供一种特异性儿茶酚衍生物，用于高效诱导未分化细胞高选择性分化为神经系统细胞，以及一种使用特异性儿茶酚衍生物高效诱导未分化细胞高选择性分化为神经系统细胞的方法。本发明的细胞分化诱导剂的特征在于包含具有特定化学结构的儿茶酚衍生物。