N-(5-azidoethanoylaminopentaneyl)propenamide;2-Propenamide, N-[5-[(2-azidoacetyl)amino]pentyl]-

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(5-azidoethanoylaminopentaneyl)propenamide;2-Propenamide, N-[5-[(2-azidoacetyl)amino]pentyl]-
• 英文别名: N-[5-[(2-azidoacetyl)amino]pentyl]prop-2-enamide
• 化学式: C10H17N5O2
• 分子量: 239.27
• InChiKey: UYORIKDXEZTMQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• ROLL-TO-ROLL PROCESS OF PREPARING A PATTERNED SUBSTRATE AND PATTERNED SUBSTRATE PREPARED BY THE SAME PROCESS
  申请人：Illumina, Inc.

  公开号：EP3572875A1

  公开（公告）日：2019-11-27

  Substrates comprising a functionalizable layer, a polymer layer comprising a plurality of micro-scale or nano-scale patterns, or combinations thereof, and a backing layer and the preparation thereof by using room-temperature UV nano-embossing processes are disclosed. The substrates can be prepared by a roll-to-roll continuous process. The substrates can be used as flow cells, nanofluidic or microfluidic devices for biological molecules analysis.

  本发明公开了由可功能化层、包含多个微米级或纳米级图案或其组合的聚合物层和背衬层组成的基材，以及通过室温紫外线纳米压花工艺制备基材的方法。基底可以通过卷对卷连续工艺制备。这些基底可用作生物分子分析的流动池、纳米流体或微流体装置。
• POLYMERS AND DNA COPOLYMER COATINGS
  申请人：Illumina Cambridge Limited

  公开号：EP3632944A1

  公开（公告）日：2020-04-08

  The present invention relates to a polymer for surface functionalization, comprising a recurring unit of Formula (IV): wherein: each R1c and R2c is independently selected from hydrogen, optionally substituted alkyl or optionally substituted phenyl; R3c is selected from hydrogen, optionally substituted alkyl, optionally substituted phenyl, or optionally substituted C7-14 aralkyl; Ar is selected from an optionally substituted C6-10 aryl or an optionally substituted 5 or 6 membered heteroaryl; RA is optionally substituted tetrazine; and L3 is selected from a single bond, an optionally substituted alkylene linker or an optionally substituted heteroalkylene linker. The invention also relates to a substrate comprising said polymer and to a method for immobilizing a polymer to a first surface of a substrate.

  本发明涉及一种用于表面官能化的聚合物，它由式（IV）的重复单元组成： 其中：每个 R1c 和 R2c 独立地选自氢、任选取代的烷基或任选取代的苯基；R3c 选自氢、任选取代的烷基、任选取代的苯基或任选取代的 C7-14 芳基；Ar 选自任选取代的 C6-10 芳基或任选取代的 5 或 6 成员杂芳基；RA 是任选取代的四嗪；以及 L3 选自单键、任选取代的亚烷基连接体或任选取代的杂烷基连接体。本发明还涉及一种包含所述聚合物的基底，以及一种将聚合物固定在基底第一表面的方法。
• POLYMER COATINGS
  申请人：Illumina, Inc.

  公开号：EP3792320A1

  公开（公告）日：2021-03-17

  The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.

  本公开涉及共价连接到基底表面的聚合物涂层和聚合物涂层的制备，例如聚(N-(5-叠氮乙酰胺戊基)丙烯酰胺-共丙烯酰胺)(PAZAM)，用于形成和操作基底，例如分子阵列和流动池。本公开还涉及通过使用涂有共价连接聚合物（如 PAZAM）的珠子制备基底表面的方法，以及确定附着在本文所述基底表面的多核苷酸的核苷酸序列的方法。
• Polymer coatings
  申请人：Illumina, Inc.

  公开号：US10266891B2

  公开（公告）日：2019-04-23

  The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.

  本公开涉及共价连接到基底表面的聚合物涂层和聚合物涂层的制备，例如聚(N-(5-叠氮乙酰胺戊基)丙烯酰胺-共丙烯酰胺)(PAZAM)，用于形成和操作基底，例如分子阵列和流动池。本公开还涉及通过使用涂有共价连接聚合物（如 PAZAM）的珠子制备基底表面的方法，以及确定附着在本文所述基底表面的多核苷酸的核苷酸序列的方法。
• Polymers and DNA copolymer coatings
  申请人：Illumina Cambridge Limited

  公开号：US10577439B2

  公开（公告）日：2020-03-03

  Some embodiments described herein relate to new polymer coatings for surface functionalization and new processes for grafting pre-grafted DNA-copolymers to surface(s) of substrates for use in DNA sequencing and other diagnostic applications.

  本文所述的一些实施方案涉及用于表面功能化的新型聚合物涂层，以及将预接枝 DNA 聚合物接枝到用于 DNA 测序和其他诊断应用的基质表面的新工艺。