2-[(1R,3R)-1-hydroxy-4-methyl-3-[[(2S)-3-methyl-2-[(1-methylpiperidine-2-carbonyl)amino]pentanoyl]-(pentoxymethyl)amino]pentyl]-1,3-thiazole-4-carboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(1R,3R)-1-hydroxy-4-methyl-3-[[(2S)-3-methyl-2-[(1-methylpiperidine-2-carbonyl)amino]pentanoyl]-(pentoxymethyl)amino]pentyl]-1,3-thiazole-4-carboxylic acid
• 化学式: C₂₉H₅₀N₄O₆S
• 分子量: 582.8
• InChiKey: PJQOKIKHMLQXJI-WBKFIFOOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  40
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  161
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• PROCESSES FOR PREPARING TUBULYSINS
  申请人：Endocyte, Inc.

  公开号：US20140249315A1

  公开（公告）日：2014-09-04

  Processes for preparing tubulysins and derivatives thereof are described. In addition, processes for preparing unnatural tubulysins are described.

  描述了制备管藿菌素及其衍生物的过程。此外，还描述了制备人工合成管藿菌素的过程。
• PROCESSES FOR PREPARING TUBULYSIN DERIVATIVES AND CONJUGATES THEREOF
  申请人：ENDOCYTE, INC.

  公开号：US20140080175A1

  公开（公告）日：2014-03-20

  The invention described herein pertains to processes for preparing tubulysin derivatives, conjugates of tubulysins, and intermediates therefore.
• PROCESS FOR PREPARING TUBULYSINS
  申请人：ENDOCYTE, INC.

  公开号：US20160016993A1

  公开（公告）日：2016-01-21

  The invention described herein pertains to processes for preparing tubulysins and derivatives thereof. The invention described herein also pertains to processes for preparing tubulysin conjugates. The invention described herein also pertains to processes for preparing intermediates for preparing tubulysin conjugates. In one step, the alpha-thiazolyl alcohol is protected with triethylsilyl chloride in the presence of imidazole in an aprotic solvent.
• US9505747B2
  申请人：——

  公开号：US9505747B2

  公开（公告）日：2016-11-29
• US9771391B2
  申请人：——

  公开号：US9771391B2

  公开（公告）日：2017-09-26