(6Z)-6-ethylidene-5-nitrocyclohexa-2,4-dien-1-imine

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: (6Z)-6-ethylidene-5-nitrocyclohexa-2,4-dien-1-imine
• 化学式: C8H8N2O2
• 分子量: 164.16
• InChiKey: DPIRXTDNWZERFV-WEWWREOGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  69.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] MINERALOCORTICOID RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DES RÉCEPTEURS AUX MINÉRALOCORTICOÏDES
  申请人：MERCK SHARP & DOHME

  公开号：WO2014014794A2

  公开（公告）日：2014-01-23

  The present invention is directed to compounds of the Formula I: as well as pharmaceutically acceptable salts thereof, that may be useful for treating aldosterone-mediated diseases. The invention furthermore relates to specific diastereomers and enantiomers of the compounds, to processes for preparing compounds of the Formula I, to their potential use for the therapy and prophylaxis of the above-mentioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula I.