(2S)-5-(diaminomethylamino)-N-[(4S,7S)-10-(diaminomethylamino)-7-[[(2S)-5-(diaminomethylamino)-2-[2-[(4S)-1-[2-[4-[2-(4-hydrazinyl-2,3-dioxobutyl)hydrazinyl]-2,3-dioxobutyl]hydrazinyl]-6-methyl-2,3-dioxoheptan-4-yl]hydrazinyl]pentanoyl]amino]-2-methyl-5,6-dioxodecan-4-yl]-2-[[(3S)-3-(methylamino)-2-oxobutyl]amino]pentanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-5-(diaminomethylamino)-N-[(4S,7S)-10-(diaminomethylamino)-7-[[(2S)-5-(diaminomethylamino)-2-[2-[(4S)-1-[2-[4-[2-(4-hydrazinyl-2,3-dioxobutyl)hydrazinyl]-2,3-dioxobutyl]hydrazinyl]-6-methyl-2,3-dioxoheptan-4-yl]hydrazinyl]pentanoyl]amino]-2-methyl-5,6-dioxodecan-4-yl]-2-[[(3S)-3-(methylamino)-2-oxobutyl]amino]pentanamide
• 化学式: C₄₅H₉₁N₂₁O₁₁
• 分子量: 1102.3
• InChiKey: GGIVMOGOUBHSEK-HPMAGDRPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.7
• 重原子数：
  77
• 可旋转键数：
  50
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  538
• 氢给体数：
  21
• 氢受体数：
  30

文献信息

• [EN] TRANSLOCATION OF NON-NATURAL CHEMICAL ENTITIES THROUGH ANTHRAX PROTECTIVE ANTIGEN PORE<br/>[FR] TRANSLOCATION D'ENTITÉS CHIMIQUES ARTIFICIELLES PAR UN PORE D'ANTIGÈNE PROTECTEUR CONTRE L'ANTHRAX
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2013177231A1

  公开（公告）日：2013-11-28

  Disclosed is a new approach for delivering compounds and drugs to the cytosol of living cells through the use of engineered protein transporters. The engineered protein transporters include a pore and a pore specific delivery protein, wherein a reagent such as a drug is attached to one or more of the engineered protein transporters.