2,5-Dioxo-1-[5-oxo-5-(pentylamino)pentanoyl]oxypyrrolidine-3-sulfonic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,5-Dioxo-1-[5-oxo-5-(pentylamino)pentanoyl]oxypyrrolidine-3-sulfonic acid
• 英文别名: 2,5-dioxo-1-[5-oxo-5-(pentylamino)pentanoyl]oxypyrrolidine-3-sulfonic acid
• 化学式: C₁₄H₂₂N₂O₈S
• 分子量: 378.4
• InChiKey: QCLREIBZRIBENQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  25
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  156
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• MACROCYCLES
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20150157746A1

  公开（公告）日：2015-06-11

  The invention provides macrocycles useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.

  这项发明提供了在螯合金属离子中特别是放射性核素中有用的大环化合物，以提供金属离子配合物。该发明还提供了使用这些化合物和配合物的方法，例如在治疗和诊断应用中。
• LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES
  申请人：RAYMOND Kenneth N.

  公开号：US20120329174A1

  公开（公告）日：2012-12-27

  The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.

  本发明提供了一类新型的大环化合物，以及由金属（例如镧系金属）离子和本发明化合物形成的配合物。优选的配合物在无需二次激活剂的情况下，在水介质中表现出高稳定性和高镧系离子荧光量子产率。优选的化合物在其大环结构中包含羟基异苯酰胺基团，并以出人意料的低非特异性结合多种多肽（如抗体和蛋白质）以及高动力学稳定性为特征。这些特征使它们与已知的开放结构配体有所区别。
• DI-MACROCYCLES
  申请人：LUMIPHORE, INC.

  公开号：US20160221971A1

  公开（公告）日：2016-08-04

  The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.

  本发明涉及可用于治疗和诊断应用的化合物和复合物。
• Hopo chelators
  申请人：Lumiphore, Inc.

  公开号：EP2816038A1

  公开（公告）日：2014-12-24

  The present invention provides a novel class of macrocyclic compounds of formula (I) as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. (I)

  本发明提供了一类新型的式(I)大环化合物以及金属（如镧系元素）离子与本发明化合物之间形成的配合物。优选的配合物在水介质中表现出高稳定性和高镧系离子发光量子产率，无需二次活化剂。优选化合物在其大环结构中包含羟基吡啶壬基，其特点是与抗体和蛋白质等多种多肽的非特异性结合率低得出奇，并且具有很高的动力学稳定性。 (I)
• HOPO CHELATORS
  申请人：Lumiphore, Inc.

  公开号：EP2816038B1

  公开（公告）日：2019-11-20