5-[[5-Fluoro-4-(4-prop-2-ynoxyanilino)pyrimidin-2-yl]amino]-2-methylbenzenesulfinamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-[[5-Fluoro-4-(4-prop-2-ynoxyanilino)pyrimidin-2-yl]amino]-2-methylbenzenesulfinamide
• 英文别名: 5-[[5-fluoro-4-(4-prop-2-ynoxyanilino)pyrimidin-2-yl]amino]-2-methylbenzenesulfinamide
• 化学式: C₂₀H₁₈FN₅O₂S
• 分子量: 411.5
• InChiKey: OBJSXHIUNYBQKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  121
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• [EN] TREATMENT FOR VITILIGO<br/>[FR] TRAITEMENT DU VITILIGO
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2014043257A1

  公开（公告）日：2014-03-20

  Compounds I and II, as well as prodrugs, hydrates, solvates, N-oxides, salts and pharmaceutical compositions containing them, are useful for treating vitiligo. In certain embodiments, the compounds are provided in topical compositions. (The chemical formulas should be inserted here.)
• [EN] COMPOSITION FOR OPHTHALMIC ADMINISTRATION<br/>[FR] COMPOSITION POUR ADMINISTRATION OPHTALMIQUE
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2014117010A2

  公开（公告）日：2014-07-31

  Disclosed herein are embodiments of a composition useful for treating and/or preventing dry eye disorders. The disclosed composition comprises components that maintain the composition' s chemical and/or physical properties thereby providing a composition suitable for use.