2,2,4-Trimethyl-4-sulfanylpentan-1-ol

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醇
• 英文名称: 2,2,4-Trimethyl-4-sulfanylpentan-1-ol
• 英文别名: 2,2,4-trimethyl-4-sulfanylpentan-1-ol
• 化学式: C₈H₁₈OS
• 分子量: 162.3
• InChiKey: DUOLZHXMLRBPIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] POLYNUCLEOTIDES HAVING BIOREVERSIBLE GROUPS<br/>[FR] POLYNUCLÉOTIDES POSSÉDANT DES GROUPES BIORÉVERSIBLES
  申请人：UNIV CALIFORNIA

  公开号：WO2014031575A1

  公开（公告）日：2014-02-27

  The disclosure provides methods and compositions for delivering polynucleotides into cells. The disclosure provides transiently protected polynucleotides comprising an anionic charge- neutralizing moiety/group, which may also confer additional functionality. These compounds can enter the cytosol of cells by endocytic or macropinocytic mechanisms. The transient protecting group is bioreversible, i.e., once inside a cell, it is designed to be removed by enzymatic activity or by passive intracellular methods (e.g., changes in pH or reductive environment).