4-[3-[[(2S)-6-[[2-[2-[2-[2-[(3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethoxy]acetyl]amino]-2-[[(2S)-2,6-bis[[2-[2-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethoxy]acetyl]amino]hexanoyl]amino]hexanoyl]amino]-3-methylbutoxy]-4-methylpentanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-[3-[[(2S)-6-[[2-[2-[2-[2-[(3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethoxy]acetyl]amino]-2-[[(2S)-2,6-bis[[2-[2-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethoxy]acetyl]amino]hexanoyl]amino]hexanoyl]amino]-3-methylbutoxy]-4-methylpentanoic acid
• 化学式: C₇₁H₁₂₈N₈O₃₅
• 分子量: 1653.8
• InChiKey: BMNHSDNXZSFTFZ-NRNCKOAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.7
• 重原子数：
  114
• 可旋转键数：
  64
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  600
• 氢给体数：
  18
• 氢受体数：
  35

文献信息

• [EN] POLY(ACRYLATE) POLYMERS FOR IN VIVO NUCLEIC ACID DELIVERY<br/>[FR] POLYMÈRES DE POLY(ACRYLATE) POUR UNE ADMINISTRATION D'ACIDE NUCLÉIQUE IN VIVO
  申请人：ARROWHEAD RES CORP

  公开号：WO2013158141A1

  公开（公告）日：2013-10-24

  The present invention is directed membrane active poly(acrylate) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides cells in vivo. RNAi polynucleotides are conjugated to the poly(acrylate) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(acrylate) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.