(2,3-dibromophenyl)phenylmethanone | 1266379-31-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,3-dibromophenyl)phenylmethanone
• 英文别名: Dibromobenzophenone；(2,3-dibromophenyl)-phenylmethanone
• CAS: 1266379-31-0
• 化学式: C₁₃H₈Br₂O
• 分子量: 340.014
• InChiKey: BZWGZQNUCNUCES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (2,3-dibromophenyl)phenylmethanone 在 lithium aluminium tetrahydride 、 sodium hydride 、 2-异丁吲哚丁醇 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 2.25h， 生成 (R)-1,2-dibromo-3-((methoxymethoxy)(phenyl)methyl)benzene
  参考文献：
  名称：

  Stereoselective Synthesis of P-Chirogenic Dibenzophosphole–Boranes via Aryne Intermediates

  摘要：

  A new aryne-mediated tandem cross-coupling/P-cyclization sequence starting from tertiary phosphine-boranes and 1,2-dibromobenzenes is reported. P-chirogenic dibenzophospholes become accessible in a regio-, chemo-, and diastereoselectiye way.

  DOI：

  10.1021/jo3009098
• 作为产物：
  描述：

  1-溴-3-碘苯 在 N-氯代丁二酰亚胺 、 异丙基氯化镁 、 lithium bromide 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 为溶剂， 反应 76.0h， 生成 (2,3-dibromophenyl)phenylmethanone
  参考文献：
  名称：

  提供获得具有合成价值的 1,2-二溴苯的高效互补方法

  摘要：

  1,2-二溴苯是各种有机转化的非常有价值的前体，特别是基于苄基中间体形成的反应。本报告描述了基于区域选择性溴化、邻位金属化和卤素/金属置换合成各种衍生物的短序列。1,2-二溴-3-碘苯 (2f)、1,2-二溴-4-碘苯 (4c) 和 2,3-二溴-1,4-二碘苯 (5e) 在这些合成中用作中间体。

  DOI：

  10.1002/ejoc.201001217

文献信息

• [EN] COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT D'INFECTIONS MICROBIENNES
  申请人：UNIV VANDERBILT

  公开号：WO2014018925A1

  公开（公告）日：2014-01-30

  Embodiments of the presently-disclosed subject matter include activators of HssRS that induce endogenous heme biosynthesis by perturbing central metabolism. These molecules are toxic to fermenting S. aureus, including clinically relevant small colony variants (SCVs). The utility of targeting fermenting bacteria is exemplified by the fact that this compound prevents the emergence of antibiotic resistance, enhances phagocyte killing, and reduces S. aureus pathogenesis. This small molecule is a powerful tool not only for studying bacterial heme biosynthesis and central metabolism, but also establishes targeting of fermentation as a viable antibacterial strategy.

  目前所披露的主题的实施例包括激活HssRS的活化剂，通过干扰中心代谢诱导内源性血红素生物合成。这些分子对发酵的金黄色葡萄球菌，包括临床相关的小菌落变异体（SCVs）具有毒性。瞄准发酵细菌的实用性可以通过这种化合物防止抗生素耐药性的出现，增强吞噬细胞杀伤力，并减少金黄色葡萄球菌的发病机制。这种小分子不仅是研究细菌血红素生物合成和中心代谢的有力工具，而且还建立了将发酵作为可行抗菌策略的瞄准方式。
• Resin comprising a polyphenylene sulfide/polyphenylene sulfone block copolymer, process for preparing the copolymer and molded article
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP0268765A2

  公开（公告）日：1988-06-01

  A resin composition comprising a block copolymer composed of polyphenylene sulfide segments and polyphenyl­ene sulfide sulfone segments and at least one polymer selected from polyphenylene sulfides, polyphenylene sul­fide sulfones, polysulfones, polyphenylene oxides, poly­arylates, polycarbonates and polyetherimides, and op­tionally a filler.

  一种树脂组合物，包含由聚苯硫醚段和聚苯硫醚砜段组成的嵌段共聚物和至少一种选自聚苯硫醚、聚苯硫醚砜、聚砜、聚苯氧化物、聚芳酯、聚碳酸酯和聚醚酰亚胺的聚合物，以及可选填料。
• Process for recovering a polyarylene sulfide
  申请人：Tosoh Corporation

  公开号：EP0271253A2

  公开（公告）日：1988-06-15

  A polyarylene sulfide having a low content of electrolytic ions is economically recovered from a mixture consisting mainly of polyarylene sulfide and an alkali metal halide which mixture is obtained by reacting a polyhaloge­nated aromatic compound and an alkali metal sulfide contain­ing water in an organic polar solvent, by dehydrating the mixture by distillation, mixing the dehydrated mixture with a solvent which is a bad solvent for both polyarylene sulfide and alkali metal halide and which is soluble in the organic polar solvent to prepare a slurry consisting essentially of the polyarylene sulfide and the alkali metal halide, subjecting the slurry to solid-liquid separation, washing the resultant cake with the bad solvent, drying the cake, adding water to the cake to wash away the alkali metal halide through dissolution, and subjecting the slurry to solid-liquid separation to recover polyarylene sulfide. Such a polyarylene sulfide is particularly useful for use in electronic and electric components and molded articles such as films, sheets and fibers.

  从主要由聚芳基硫醚和碱金属卤化物组成的混合物中经济地回收电解离子含量低的聚芳基硫醚，该混合物是由多卤代芳香族化合物和含水的碱金属硫化物在有机极性溶剂中反应，通过蒸馏使混合物脱水而得到的、将脱水后的混合物与一种对聚芳基硫醚和碱金属卤化物都是不良溶剂且可溶于有机极性溶剂的溶剂混合，制备出一种主要由聚芳基硫醚和碱金属卤化物组成的浆料、将淤浆进行固液分离，用劣质溶剂洗涤所得滤饼，干燥滤饼，向滤饼中加水以通过溶解洗去碱金属卤化物，然后将淤浆进行固液分离以回收聚芳基硫醚。这种聚芳基硫醚特别适用于电子和电气元件以及薄膜、薄片和纤维等模制产品。
• Thermoplastic resin composition
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP0275991A2

  公开（公告）日：1988-07-27

  A resin composition comprising (a) 100 parts by weight of a block copolymer composed of polyphenylene sulfide segments and polyphenylene sulfide sulfone seg­ments and (b) 0.01 to 20 parts by weight of at least one compound selected from the group consisting of epoxy resins, maleimide compounds, N,N'-diarylcarbodiimide compounds and organosilane compounds and as required, (c) an inorganic filler.

  一种树脂组合物，其成分包括：(a) 100 重量份的由聚苯硫醚段和聚苯硫醚砜段组成的嵌段共聚物；(b) 0.01 至 20 重量份的至少一种选自环氧树脂、马来酰亚胺化合物、N,N'-二芳基碳二亚胺化合物和有机硅化合物组成的组中的化合物；以及根据需要，(c) 一种无机填料。
• Stretched poly(arylene thioether-ketone) films and production process thereof
  申请人：KUREHA KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0293113A2

  公开（公告）日：1988-11-30

  Disclosed herein is a stretched poly(arylene thioether-ketone) film made of a thermoplastic material which comprises (A) 100 parts by weight of a melt-­stable poly(arylene thioether-ketone) having predomi­nant recurring units of the formula and having a melting point, Tm of 310-380°C, a residual melt crystallization enthalpy, ΔHmc (420°C/10 min) of at least 10 J/g and a melt crystallization temperature, Tmc (420°C/10 min) of at least 210°C, and a reduced viscosity of 0.3-2 dℓ/g as determined by viscosity measurement at 25°C and a polymer concentration of 0.5 g/dℓ in 98 percent by weight sulfuric acid; and optionally, (B) up to 100 parts by weight of at least one of thermoplastic resins and/or up to 15 parts by weight of at least one of fillers. Its production process is also disclosed.

  本发明公开了一种由热塑性材料制成的拉伸聚(芳基硫醚酮)薄膜，该热塑性材料包括 (A) 100 份(重量)熔融稳定的聚(芳基硫醚酮)，该聚(芳基硫醚酮)的主要递归单元式为 熔点 Tm 为 310-380°C，残余熔融结晶焓 ΔHmc (420°C/10 min) 至少为 10 J/g，熔融结晶温度 Tmc (420°C/10 min) 至少为 210°C，还原粘度为 0.3-2 dℓ/g （通过在 25°C 下测量粘度确定），聚合物浓度为 0.5 g/dℓ （在 98% 重量的硫酸中）；以及 (B) 最多 100 份（重量）的至少一种热塑性树脂和/或最多 15 份（重量）的至少一种填料。其生产工艺也已公开。