(2R)-2-(4-aminobutyl)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]-[(2S)-2,6-diaminohexanoyl]peroxyamino]-3-oxooctadecanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-(4-aminobutyl)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]-[(2S)-2,6-diaminohexanoyl]peroxyamino]-3-oxooctadecanoic acid
• 化学式: C₃₃H₆₅N₅O₇S
• 分子量: 676.0
• InChiKey: KYXUBKZKOXTTQA-NTBNWUQQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  46
• 可旋转键数：
  33
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  240
• 氢给体数：
  5
• 氢受体数：
  12

文献信息

• Cosmetic composition for increasing hyaluronic acid synthesis in skin and its use for repairing wrinkles
  申请人：COTY GERMANY GMBH

  公开号：EP2732806A1

  公开（公告）日：2014-05-21

  The present invention relates to a skin composition which has an excellent effect on smoothing or repairing wrinkles. The composition comprises Palmitoyl Tripeptide-38 (Palmitoyl-Lysyl-Dioxymethionyl-Lysine) and Piper nigrum (Pepper) seed Extract which combination has been found to result in a synergistic effect on hyaluronan synthase 1 (HAS1) mRNA expression in human fibroblasts. The hyaluronan synthase is responsible for the synthesis of hyaluronan (hyaluronic acid) in skin. Hyaluronic acid is a constituent of the extracellular matrix of the skin and responsible for space filling, tissue repair and retention of moisture.

  本发明涉及一种在抚平或修复皱纹方面具有卓越功效的皮肤组合物。该组合物包含棕榈酰三肽-38（棕榈酰-赖氨酰-二氧蛋氨酰-赖氨酸）和胡椒籽提取物，研究发现这两种成分的结合可对人成纤维细胞中透明质酸合成酶 1 (HAS1) mRNA 的表达产生协同作用。透明质酸合成酶负责合成皮肤中的透明质酸。透明质酸是皮肤细胞外基质的成分，负责填充空间、组织修复和保持水分。
• COSMETIC COMPOSITION FOR INCREASING HYALURONIC ACID SYNTHESIS IN SKIN AND ITS USE FOR REPAIRING WRINKLES
  申请人：COTY GERMANY GMBH

  公开号：US20140301960A1

  公开（公告）日：2014-10-09

  The present invention relates to a skin composition which has an excellent effect on smoothing or repairing wrinkles. The composition comprises Palmitoyl Tripeptide-38 (Palmitoyl-Lysyl-Dioxymethionyl-Lysine) and Piper nigrum (Pepper) seed Extract which combination has been found to result in a synergistic effect on hyaluronan synthase 1 (HAS1) mRNA expression in human fibroblasts. The hyaluronan synthase is responsible for the synthesis of hyaluronan (hyaluronic acid) in skin. Hyaluronic acid is a constituent of the extracellular matrix of the skin and responsible for space filling, tissue repair and retention of moisture.
• US9149659B2
  申请人：——

  公开号：US9149659B2

  公开（公告）日：2015-10-06
• [EN] FAST-PENETRATION COSMETIC DERMAL FILLER FOR TOPICAL APPLICATION<br/>[FR] CHARGE DERMIQUE À USAGE COSMÉTIQUE ET À PÉNÉTRATION RAPIDE POUR APPLICATION TOPIQUE
  申请人：LABO COSPROPHAR AG

  公开号：WO2014044808A2

  公开（公告）日：2014-03-27

  The present invention relates to a cosmetic dermal composition or dermal filler based on a mixture of hyaluronic acids having specific molecular weights. The cosmetic dermal composition is suitable for filling or relaxing wrinkles, depressions or microreliefs of the skin or for increasing the volume of areas of the human body affected by skin aging such as face, lips, breasts, gluteus, thighs.
• [EN] EXOSOME DELIVERY OF SKIN CARE PEPTIDES<br/>[FR] ADMINISTRATION D'EXOSOMES DE PEPTIDES DE SOIN CUTANÉ
  申请人：INTREXON CORP

  公开号：WO2020018926A1

  公开（公告）日：2020-01-23

  Skin care compositions comprising milk derived exosomes loaded with single skin peptide or a combination of skin peptides and methods for use in skin treatment are described.