(2S,3S,4S,5S,6R)-2-dodecoxy-6-methyloxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2S,3S,4S,5S,6R)-2-dodecoxy-6-methyloxane-3,4,5-triol
• 化学式: C₁₈H₃₆O₅
• 分子量: 332.5
• InChiKey: JYHGYVMSXVZCRF-ZBRFXRBCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  79.2
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• ANTI-DANDRUFF SUGARS
  申请人：L'OREAL

  公开号：US20150250698A1

  公开（公告）日：2015-09-10

  The invention relates to the cosmetic use of at least one compounds according to the following formula (I), as an anti-dandruff agent or for preventing and/or treating scalp dandruff: where “sugar” denotes a monosaccharide residue chosen from rhamnose, xylose, fucose, mannose, lyxose, and arabinose; where R, substituting the anomeric oxygen in the sugar (represented by “O” in formula (I)), denotes a radical comprising 6 to 38 carbon atoms chosen from: —a linear or branched, saturated alkyl radical; —a linear or branched, alkenyl radical; said linear or branched saturated alkyl radical being optionally substituted by at least one OH and/or NH2 function; —if “sugar” denotes a mannose residue, R denotes a linear C6-C38 alkyl radical, substituted by at least one OH function or an NH2 function; and the salts and solvates and/or optical isomers thereof, alone or in a mixture, particularly racemic forms. The invention also relates to compounds according to formula (I), and cosmetic compositions containing same.

  本发明涉及至少一种根据以下公式（I）的化合物的化妆品用途，作为抗屑剂或用于预防/治疗头皮屑：其中“糖”表示一个单糖残基，选自鼠李糖、木糖、岩藻糖、甘露糖、来苏糖和阿拉伯糖；其中R代表糖（由公式（I）中的“O”表示）的异构氧上的一个基团，该基团包含6至38个碳原子，选自以下几种：—线性或支链的饱和烷基；—线性或支链的烯丙基；所述的线性或支链的饱和烷基可选择性地被至少一个OH和/或NH2功能基团取代；—如果“糖”表示一个甘露糖残基，R表示一个线性的C6-C38烷基，被至少一个OH功能或NH2功能取代；以及所述化合物的盐、溶剂化物和/或光学异构体，单独或混合使用，尤其是外消旋形式。本发明还涉及根据公式（I）的化合物，以及含有该化合物的化妆品组合物。
• US9833397B2
  申请人：——

  公开号：US9833397B2

  公开（公告）日：2017-12-05
• [EN] ANTI-DANDRUFF SUGARS<br/>[FR] SUCRES ANTIPELLICULAIRES
  申请人：OREAL

  公开号：WO2014044779A2

  公开（公告）日：2014-03-27

  The invention relates to the cosmetic use of at least one compounds according to the following formula (I), as an anti-dandruff agent or for preventing and/or treating scalp dandruff: where "sugar" denotes a monosaccharide residue chosen from rhamnose, xylose, fucose, mannose, lyxose, and arabinose; where R, substituting the anomeric oxygen in the sugar (represented by "O" in formula (I)), denotes a radical comprising 6 to 38 carbon atoms chosen from: - a linear or branched, saturated alkyl radical; - a linear or branched, alkenyl radical; said linear or branched saturated alkyl radical being optionally substituted by at least one OH and/or NH2 function; - if "sugar" denotes a mannose residue, R denotes a linear C6-C38 alkyl radical, substituted by at least one OH function or an NH2 function; and the salts and solvates and/or optical isomers thereof, alone or in a mixture, particularly racemic forms. The invention also relates to compounds according to formula (I), and cosmetic compositions containing same.
• [EN] SYNTHETIC DISUGAR HYDROCARBONS AS NATURAL ANALOGOS TO CONTROL MICROBIAL BEHAVIORS<br/>[FR] HYDROCARBURES DISUCRES SYNTHÉTIQUES UTILISÉS COMME ANALOGUES NATURELS POUR CONTRÔLER LES COMPORTEMENTS MICROBIENS
  申请人：LUK YAN-YEUNG

  公开号：WO2015153961A1

  公开（公告）日：2015-10-08

  Synthetic disaccharide hydrocarbons (DSHs) that reactive bacterials swarming motility and inhibit bacterial adhesion and biofilm formation. A library of DSHs were tested in several experiment for the impact on various Pseudomonas aeruginosa populations and compared against existing compounds to determine efficacy and utility. Certain DSHs were also to determine the ability to clear bacteria in a mouse pneumonia model.