4-(2-{2-[2-Azido-ethoxy]-ethoxy}-ethoxy)-pyridine-2,6-dicarboxylic acid diethyl ester | 530151-57-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(2-{2-[2-Azido-ethoxy]-ethoxy}-ethoxy)-pyridine-2,6-dicarboxylic acid diethyl ester
• 英文别名: diethyl 4-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]pyridine-2,6-dicarboxylate
• CAS: 530151-57-6
• 化学式: C₁₇H₂₄N₄O₇
• 分子量: 396.4
• InChiKey: GZRNRIINTZCYCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  28
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  4-(2-{2-[2-Azido-ethoxy]-ethoxy}-ethoxy)-pyridine-2,6-dicarboxylic acid diethyl ester 在 sodium tetrahydroborate 、 calcium chloride 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以86%的产率得到(4-{2-[2-(2-Azido-ethoxy)-ethoxy]-ethoxy}-6-hydroxymethyl-pyridin-2-yl)-methanol
  参考文献：
  名称：

  Synthesis of Metal-Chelating Lipids to Sensitize Lanthanide Ions

  摘要：

  Sensitization of lanthanide ions is important for lanthanide ion-based assays and sensing. To the best of our knowledge, there are very few reports of lanthanide ion sensitization after it is incorporated into the liposome surface. This paper describes the syntheses of several saturated and polymerizable metal-chelating lipids based on chelidamic acid. The lipids are synthesized either from (S)-ornithine or racemic 2,3-diaminopropanoic acid. These lipids as well as polymerized liposomes incorporating these lipids sensitize lanthanide ions. Liposomes from the lipid 18-Eu3+ provided a probe that relies not only on the emission wavelengths of Eu3+ but also on a reproducible lifetime that can be used for protein identification.

  DOI：

  10.1021/jo026833k
• 作为产物：
  描述：

  2-[2-(2-叠氮基乙氧基)乙氧基]乙醇 在 三溴化磷 、 potassium carbonate 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 27.0h， 生成 4-(2-{2-[2-Azido-ethoxy]-ethoxy}-ethoxy)-pyridine-2,6-dicarboxylic acid diethyl ester
  参考文献：
  名称：

  Synthesis of Metal-Chelating Lipids to Sensitize Lanthanide Ions

  摘要：

  Sensitization of lanthanide ions is important for lanthanide ion-based assays and sensing. To the best of our knowledge, there are very few reports of lanthanide ion sensitization after it is incorporated into the liposome surface. This paper describes the syntheses of several saturated and polymerizable metal-chelating lipids based on chelidamic acid. The lipids are synthesized either from (S)-ornithine or racemic 2,3-diaminopropanoic acid. These lipids as well as polymerized liposomes incorporating these lipids sensitize lanthanide ions. Liposomes from the lipid 18-Eu3+ provided a probe that relies not only on the emission wavelengths of Eu3+ but also on a reproducible lifetime that can be used for protein identification.

  DOI：

  10.1021/jo026833k

文献信息

• Cytotoxic Agents Comprising New Tomaymycin Derivatives
  申请人：GAUZY Laurence

  公开号：US20090036431A1

  公开（公告）日：2009-02-05

  The present invention is related to new tomaymycin derivatives, their process of preparation and their therapeutic uses.

  本发明涉及新的托马霉素衍生物，它们的制备过程及其治疗用途。
• Cytotoxic agents comprising new tomaymycin derivatives
  申请人：sanofi-aventis

  公开号：US08163736B2

  公开（公告）日：2012-04-24

  The present invention is related to new tomaymycin derivatives, their process of preparation and their therapeutic uses.

  本发明涉及新的托马霉素衍生物、它们的制备过程和治疗用途。
• Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use
  申请人：SANOFI

  公开号：EP2371827A1

  公开（公告）日：2011-10-05

  The present invention is related to new tomaymycin derivatives of the following formula, their process of preparation and their therapeutic uses. wherein M and L are as specified in the claims.

  本发明涉及下式的新托美霉素衍生物、其制备过程及其治疗用途。 其中 M 和 L 如权利要求中所述。
• Cytotoxiv agents comprising new tomaymycin derivatives and their therapeutic use
  申请人：SANOFI

  公开号：EP2386559A1

  公开（公告）日：2011-11-16

  The present invention is related to new tomaymycin derivatives of formula (I), their process of preparation and their therapeutic uses.

  本发明涉及式（I）的新型托美霉素衍生物、其制备工艺及其治疗用途。
• CYTOTOXIC AGENTS COMPRISING NEW TOMAYMYCIN DERIVATIVES AND THEIR THERAPEUTIC USE
  申请人：Sanofi-Aventis

  公开号：EP1981889A1

  公开（公告）日：2008-10-22