申请人:Abbott Diabetes Care Inc.
公开号:US10004439B2
公开(公告)日:2018-06-26
Ceria nanoparticle compositions for use as electrode materials for in vivo electrochemical analyte sensors (e.g., glucose sensors) are provided, for example to form a cathode or a reference electrode. The ceria nanoparticle compositions may be combined with a conductive material (e.g., mixed with) to form the cathode or the reference electrode, or the ceria nanoparticle compositions may be deposited over conductive material to form the cathode or the reference electrode. Electrochemical in vivo sensors for monitoring the concentration of an analyte having a reference electrode and/or a cathode that includes a ceria nanoparticle composition, and methods for monitoring an analyte concentration using the electrochemical sensors are also described. Methods of making in vivo electrochemical analyte sensors having a reference electrode and/or a cathode that includes a ceria nanoparticle composition are also provided.
提供了用作体内电化学分析传感器(如葡萄糖传感器)电极材料的铈纳米粒子组合物,例如用于形成阴极或参比电极。铈纳米粒子组合物可与导电材料结合(如混合)以形成阴极或参比电极,或将铈纳米粒子组合物沉积在导电材料上以形成阴极或参比电极。此外,还描述了用于监测分析物浓度的体内电化学传感器,该传感器具有参比电极和/或包括铈纳米粒子组合物的阴极,以及使用该电化学传感器监测分析物浓度的方法。还提供了制作体内电化学分析传感器的方法,该传感器具有参比电极和/或包括铈纳米粒子组合物的阴极。