1,11-bis(2,6-dicarboxypyridin-4-yloxy)-3,6,9-trioxaundecane | 612040-52-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,11-bis(2,6-dicarboxypyridin-4-yloxy)-3,6,9-trioxaundecane
• 英文别名: 1,11-Bis(2,6-dicarboxypyridin-4-yloxy)-3,6,9-trioxaundecan；4-[2-[2-[2-[2-(2,6-dicarboxypyridin-4-yl)oxyethoxy]ethoxy]ethoxy]ethoxy]pyridine-2,6-dicarboxylic acid
• CAS: 612040-52-5
• 化学式: C₂₂H₂₄N₂O₁₃
• 分子量: 524.438
• InChiKey: IEMSJGZPOLPEKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  37
• 可旋转键数：
  18
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  221
• 氢给体数：
  4
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  zinc(II) nitrate hexahydrate 、 1,11-bis(2,6-dicarboxypyridin-4-yloxy)-3,6,9-trioxaundecane 在 sodium hydroxide 作用下， 以 further solvent(s) 为溶剂， 生成 Zn(1,11-bis(2,6-dicarboxypyridin-4-yloxy)-3,6,9-trioxaundecane(-4H))
  参考文献：
  名称：

  Stability of Complex Coacervate Core Micelles Containing Metal Coordination Polymer

  摘要：

  We report on the stability of complex coacervate core micelles, i.e., C3Ms (or PIC, BIC micelles), containing metal coordination polymers. In aqueous solutions these micelles are formed between charged-neutral diblock copolymers and oppositely charged coordination polymers formed from metal ions and bisligand molecules. The influence of added salt, polymer concentration, and charge composition was investigated by using light scattering and cryo-TEM techniques. The scattering intensity decreases strongly with increasing salt concentration until a critical salt concentration beyond which no micelles exist. The critical micelle concentration increases almost exponentially with the salt concentration. From the scattering results it follows that the aggregation number decreases with the square root of the salt concentration, but the hydrodynamic radius remains constant or increases slightly. It was concluded that the density of the core decreases with increasing ionic strength. This is in agreement with theoretical predictions and is also confirmed by cryo-TEM measurements. A complete composition diagram was constructed based on the composition boundaries obtained from light scattering titrations.

  DOI：

  10.1021/jp8044059
• 作为产物：
  描述：

  4-氧代-1,4-二氢-2,6-吡啶二甲酸 在 sodium hydroxide 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 50.0h， 生成 1,11-bis(2,6-dicarboxypyridin-4-yloxy)-3,6,9-trioxaundecane
  参考文献：
  名称：

  Synthesis of Novel Multifunctional Pyridine-2,6-dicarboxylic Acid Derivatives

  摘要：

  Eleven novel multifunctional compounds with pyridine-2,6-dicarboxylic acid were synthesized by hydrolyzing of ester prepared by coupling of diethyl 4-hydroxypyridine-2,6-dicarboxylate to bis-halo-hydrocarbon or bis-halide. All of the new compounds were characterized by H-1 NMR, MS, IR and EA.

  DOI：

  10.1081/scc-120017186

文献信息

• Synthesis of Novel Multifunctional Pyridine-2,6-dicarboxylic Acid Derivatives
  作者：Xian-Hong Yin、Min-Yu Tan

  DOI：10.1081/scc-120017186

  日期：2003.1.5

  Eleven novel multifunctional compounds with pyridine-2,6-dicarboxylic acid were synthesized by hydrolyzing of ester prepared by coupling of diethyl 4-hydroxypyridine-2,6-dicarboxylate to bis-halo-hydrocarbon or bis-halide. All of the new compounds were characterized by H-1 NMR, MS, IR and EA.
• Stability of Complex Coacervate Core Micelles Containing Metal Coordination Polymer
  作者：Yun Yan、Arie de Keizer、Martien A. Cohen Stuart、Markus Drechsler、Nicolaas A. M. Besseling

  DOI：10.1021/jp8044059

  日期：2008.9.4

  We report on the stability of complex coacervate core micelles, i.e., C3Ms (or PIC, BIC micelles), containing metal coordination polymers. In aqueous solutions these micelles are formed between charged-neutral diblock copolymers and oppositely charged coordination polymers formed from metal ions and bisligand molecules. The influence of added salt, polymer concentration, and charge composition was investigated by using light scattering and cryo-TEM techniques. The scattering intensity decreases strongly with increasing salt concentration until a critical salt concentration beyond which no micelles exist. The critical micelle concentration increases almost exponentially with the salt concentration. From the scattering results it follows that the aggregation number decreases with the square root of the salt concentration, but the hydrodynamic radius remains constant or increases slightly. It was concluded that the density of the core decreases with increasing ionic strength. This is in agreement with theoretical predictions and is also confirmed by cryo-TEM measurements. A complete composition diagram was constructed based on the composition boundaries obtained from light scattering titrations.