3-[(2-Methylpropan-2-yl)oxycarbonyl]-2-(3,3,3-trifluoropropyl)hexanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-[(2-Methylpropan-2-yl)oxycarbonyl]-2-(3,3,3-trifluoropropyl)hexanoic acid
• 英文别名: 3-[(2-methylpropan-2-yl)oxycarbonyl]-2-(3,3,3-trifluoropropyl)hexanoic acid
• 化学式: C₁₄H₂₃F₃O₄
• 分子量: 312.32
• InChiKey: MRATYHJQJKDKDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• FLUOROALKYL DIBENZODIAZEPINONE COMPOUNDS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2897938A1

  公开（公告）日：2015-07-29
• [EN] FLUOROALKYL DIBENZODIAZEPINONE COMPOUNDS<br/>[FR] COMPOSÉS FLUOROALKYL BENZODIAZÉPINONES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014047370A1

  公开（公告）日：2014-03-27

  Disclosed are compounds of Formula (I): wherein R1 is CH2CH2CF3 or CH2CH2CH3; R2 is CH2CH2CF3, CH2CH2CH3, CH2(cyclopropyl), phenyl, or; R3 is H; Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.