2-Tert-butyl-4-propan-2-ylmorpholine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2-Tert-butyl-4-propan-2-ylmorpholine
• 英文别名: 2-tert-butyl-4-propan-2-ylmorpholine
• 化学式: C₁₁H₂₃NO
• 分子量: 185.31
• InChiKey: LGKNOLHJSXHHRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• SUBSTITUTED ZIRCONOCENES CATALYSTS AND METHODS OF USE IN POLYMERIZATION REACTIONS
  申请人：Equistar Chemicals, LP

  公开号：US20150284490A1

  公开（公告）日：2015-10-08

  The present disclosure relates to metallocene catalysts for use in polymerization processes. Such catalysis may be used to generate long chain polymers with low long chain branching and high molecular weights. Additionally, the size of the polymers produced can be controlled by modifying the ratio of MAO or other activator to metallocene catalyst.

  本公开涉及用于聚合过程中的茂金属催化剂。这种催化作用可用于生成具有低长链分支和高分子量的长链聚合物。此外，通过修改MAO或其他活化剂与茂金属催化剂的比例，可以控制所产生聚合物的大小。
• CATALYST PERFORMANCE IN PROPYLENE EPOXIDATION
  申请人：Lyondell Chemical Technology, L.P.

  公开号：US20160297782A1

  公开（公告）日：2016-10-13

  The present disclosure relates to a method of epoxidizing an olefin to form an epoxide, the method comprising contacting an alkene (C≦12) or aralkene (C≦12) with a titanium silica catalyst, a peroxide, a buffer, and one or more organic solvents in a reaction mixture, wherein the one or more organic solvents comprise a first organic solvent selected from: R 1 —OH  (I), R 2 —CN  (II), R 3 —C(O)—R 4 (III) or R 5 —O—R 6 (IV) wherein: R 1 is alkyl (C≦12) , aryl (C≦12) , aralkyl (C≦12) or a substituted version of any of these groups; R 2 is alkyl (C≦12) , aryl (C≦12) , aralkyl (C≦12) or a substituted version of any of these groups; R 3 is hydrogen, alkyl (C≦6) or substituted alkyl (C≦6) ; and R 4 , R 5 , and R 6 are each independently selected from alkyl (C≦12) , aryl (C≦12) , aralkyl (C≦12) or a substituted version of any of these groups, or are taken together are alkoxydiyl (C≦12) , alkanediyl (C≦12) , substituted alkoxydiyl (C≦12) or substituted alkanediyl (C≦12) .

  本公开涉及一种环氧化烯烃形成环氧化物的方法，该方法包括将烯烃(C≦12)或芳基烯烃(C≦12)与钛硅催化剂、过氧化物、缓冲剂和一个或多个有机溶剂接触于反应混合物中，其中一个或多个有机溶剂包括从以下第一有机溶剂中选择的：R1—OH  (I)、R2—CN  (II)、R3—C(O)—R4(III)或R5—O—R6(IV)，其中：R1为烷基(C≦12)、芳基(C≦12)、芳基烷基(C≦12)或这些基团的取代版本；R2为烷基(C≦12)、芳基(C≦12)、芳基烷基(C≦12)或这些基团的取代版本；R3为氢、烷基(C≦6)或取代烷基(C≦6)；且R4、R5和R6各自独立地选择自烷基(C≦12)、芳基(C≦12)、芳基烷基(C≦12)或这些基团的取代版本，或者一起选自烷氧基二基(C≦12)、烷基二基(C≦12)、取代烷氧基二基(C≦12)或取代烷基二基(C≦12)。
• NON-BRIDGED METALLOCENE COMPLEXES FOR THE POLYMERIZATION OF OLEFINS
  申请人：Equistar Chemicals, LP

  公开号：US20150284489A1

  公开（公告）日：2015-10-08

  The present disclosure relates to metallocene catalyst and the use thereof to make polyolefins. In particular, the present disclosure relates to silyl-functionalized metallocene catalyst and the use of the silyl-functionalized metallocene catalyst to polymerize olefins and yield a polyolefin. Also, the present disclosure relates to a method for producing a polyolefin comprising at least the step of contacting an olefin with a metallocene catalyst to produce a polyolefin. In particular, the present disclosure provides a method for producing a polyolefin comprising the step of contacting an olefin with a silyl-functionalized metallocene catalyst.

  本公开涉及金属茂嗪催化剂及其用于制备聚烯烃的用途。特别地，本公开涉及硅烷功能化金属茂嗪催化剂以及使用该催化剂聚合烯烃并产生聚烯烃的用途。此外，本公开还涉及一种制备聚烯烃的方法，其中至少包括与金属茂嗪催化剂接触的步骤以产生聚烯烃。特别地，本公开提供了一种制备聚烯烃的方法，其包括将烯烃与硅烷功能化金属茂嗪催化剂接触的步骤。
• BIPHENYLAMIDE DERIVATIVE HSP90 INHIBITORS
  申请人：THE UNIVERSITY OF KANSAS

  公开号：US20160272584A1

  公开（公告）日：2016-09-22

  Compounds of the formulas are provided: wherein variables Y 1 -Y 5 , X 1 -X 5 , A 1 -A 4 , X, y, n 1 , n 2 , and R 1 -R 15 are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are useful for the treatment of a disease or disorder, including, for example, a proliferative disease, such as cancer.

  提供以下化合物的公式：其中变量Y1-Y5，X1-X5，A1-A4，X，y，n1，n2和R1-R15如本文所定义。还提供了这些化合物的药物组合物。在某些方面，这些化合物可用于治疗疾病或疾病，包括例如增生性疾病，如癌症。
• Coumarin based Hsp90 inhibitors with urea and ether substituents
  申请人：University of Kansas

  公开号：US10030006B2

  公开（公告）日：2018-07-24

  Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.

  提供了以下式子的化合物： 其中：提供了 R1-R4、X1、Y1 和 A 如本文所定义的化合物。还提供了这些化合物的药物组合物。在某些方面，这些化合物可用于治疗疾病或紊乱。在某些实施方案中，疾病或紊乱是增殖性疾病，如癌症。