1-Pyrazinoyl-4-ethylthiosemicarbazid | 37547-11-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-Pyrazinoyl-4-ethylthiosemicarbazid
• 英文别名: TAACF 417780；4-ethyl-1-(pyrazine-2-carbonyl)-thiosemicarbazide；1-Ethyl-3-(pyrazine-2-carbonylamino)thiourea
• CAS: 37547-11-8
• 化学式: C₈H₁₁N₅OS
• 分子量: 225.274
• InChiKey: ZZZFSBHZPPHVQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  111
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  吡嗪-2-甲酰肼 、 异硫氰酸乙酯 以 乙醇 为溶剂， 以82.2%的产率得到1-Pyrazinoyl-4-ethylthiosemicarbazid
  参考文献：
  名称：

  Synthesis and anti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives

  摘要：

  A series of pyrazine-2-carboxylic acid hydrazide derivatives were synthesized and screened for their activity against Mycobacterium tuberculosis. The results show that pyrazine-2-carboxylic acid hydrazide hydrazone derivatives 3a-1 were less active than pyrazinamide. In contrast, the N-4-ethyl-N-1-pyrazinoyl-thiosemicarbazide 4 showed the highest activity against M. tuberculosis H(37)Rv (IC90 = 16.87 mu g/mL). Details of the structure-activity and structure-cytotoxicity relationships are discussed. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.04.025

文献信息

• Synthesis and anti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives
  作者：Mohamed Abdel-Aziz、Hamdy M. Abdel-Rahman

  DOI：10.1016/j.ejmech.2010.04.025

  日期：2010.8

  A series of pyrazine-2-carboxylic acid hydrazide derivatives were synthesized and screened for their activity against Mycobacterium tuberculosis. The results show that pyrazine-2-carboxylic acid hydrazide hydrazone derivatives 3a-1 were less active than pyrazinamide. In contrast, the N-4-ethyl-N-1-pyrazinoyl-thiosemicarbazide 4 showed the highest activity against M. tuberculosis H(37)Rv (IC90 = 16.87 mu g/mL). Details of the structure-activity and structure-cytotoxicity relationships are discussed. (C) 2010 Elsevier Masson SAS. All rights reserved.