ethyl (2R)-2-(benzhydrylideneamino)-3-naphthalen-1-ylpropanoate | 677005-00-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl (2R)-2-(benzhydrylideneamino)-3-naphthalen-1-ylpropanoate
• CAS: 677005-00-4
• 化学式: C₂₈H₂₅NO₂
• 分子量: 407.512
• InChiKey: VJMJEGTZAKWHOK-AREMUKBSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl (2R)-2-(benzhydrylideneamino)-3-naphthalen-1-ylpropanoate 在 盐酸 、 碳酸氢钠 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 生成
  参考文献：
  名称：

  Highly enantioselective alkylation of glycine methyl and ethyl ester derivatives under phase-transfer conditions: its synthetic advantage

  摘要：

  Phase-transfer alkylation of the benzophenone Schiff base of glycine methyl or ethyl ester (2) was found to be catalyzed by 3,4,5-F-3-C6H2-NAS-Br [(S,S)-1] with high efficiency and excellent enantioselectivity. This procedure allows facile derivatization of the resulting alkylation products to other synthetically useful chiral building blocks. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.12.102
• 作为产物：
  描述：

  二苯亚甲基甘氨酸乙酯 、 1-溴甲基萘 在 氢氧化钾 、 3,4,5-F₃-C₆H₂-NAS-Br 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以99%的产率得到ethyl (2R)-2-(benzhydrylideneamino)-3-naphthalen-1-ylpropanoate
  参考文献：
  名称：

  Highly enantioselective alkylation of glycine methyl and ethyl ester derivatives under phase-transfer conditions: its synthetic advantage

  摘要：

  Phase-transfer alkylation of the benzophenone Schiff base of glycine methyl or ethyl ester (2) was found to be catalyzed by 3,4,5-F-3-C6H2-NAS-Br [(S,S)-1] with high efficiency and excellent enantioselectivity. This procedure allows facile derivatization of the resulting alkylation products to other synthetically useful chiral building blocks. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.12.102

文献信息

• Highly enantioselective alkylation of glycine methyl and ethyl ester derivatives under phase-transfer conditions: its synthetic advantage
  作者：Takashi Ooi、Yukitaka Uematsu、Keiji Maruoka

  DOI：10.1016/j.tetlet.2003.12.102

  日期：2004.2

  Phase-transfer alkylation of the benzophenone Schiff base of glycine methyl or ethyl ester (2) was found to be catalyzed by 3,4,5-F-3-C6H2-NAS-Br [(S,S)-1] with high efficiency and excellent enantioselectivity. This procedure allows facile derivatization of the resulting alkylation products to other synthetically useful chiral building blocks. (C) 2003 Elsevier Ltd. All rights reserved.