2-(dimethylamino)-N-[2,6-di(propan-2-yl)phenyl]acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(dimethylamino)-N-[2,6-di(propan-2-yl)phenyl]acetamide
• 化学式: C₁₆H₂₆N₂O
• 分子量: 262.39
• InChiKey: HXZJWEYKWOUBSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Lipid construct for delivery of insulin to a mammal
  申请人：SDG, INC.

  公开号：US10463616B2

  公开（公告）日：2019-11-05

  The instant invention is drawn to a hepatocyte targeted composition comprising insulin associated with a lipid construct comprising an amphipathic lipid and an extended amphipathic lipid that targets the construct to a receptor displayed by an hepatocyte. The composition can comprise a mixture of free insulin and insulin associated with the complex. The composition can be modified to protect insulin and the complex from degradation. The invention also includes methods for the manufacture of the composition and loading insulin into the composition and recycling various components of the composition. Methods of treating individuals inflicted with diabetes.

  本发明涉及一种肝细胞靶向组合物，该组合物包含与脂质构建物相关联的胰岛素，脂质构建物包括两性脂质和扩展两性脂质，该构建物可靶向肝细胞显示的受体。该组合物可包括游离胰岛素和与复合物相关的胰岛素的混合物。可以对组合物进行修饰，以保护胰岛素和复合物不被降解。本发明还包括制造组合物、将胰岛素装入组合物以及回收组合物中各种成分的方法。治疗糖尿病患者的方法。
• LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL
  申请人：SDG, INC.

  公开号：US20190054021A1

  公开（公告）日：2019-02-21

  The instant invention is drawn to a hepatocyte targeted composition comprising insulin associated with a lipid construct comprising an amphipathic lipid and an extended amphipathic lipid that targets the construct to a receptor displayed by an hepatocyte. The composition can comprise a mixture of free insulin and insulin associated with the complex. The composition can be modified to protect insulin and the complex from degradation. The invention also includes methods for the manufacture of the composition and loading insulin into the composition and recycling various components of the composition. Methods of treating individuals inflicted with diabetes.