2-methyl-N-propan-2-yl-2-(propan-2-ylamino)propanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-methyl-N-propan-2-yl-2-(propan-2-ylamino)propanamide
• 化学式: C₁₀H₂₂N₂O
• 分子量: 186.29
• InChiKey: IRELQTXIATYPIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• IAP ANTAGONISTS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20150322111A1

  公开（公告）日：2015-11-12

  There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

  公开了化合物(I)的配方，该化合物调节凋亡抑制剂(IAPs)的活性，包含该化合物的药物组合物以及利用本发明的化合物治疗增生性疾病和失调凋亡疾病，如癌症的方法。
• [EN] NOVEL CXCR4-TARGETING COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS CIBLANT CXCR4
  申请人：PROVINCIAL HEALTH SERVICES AUTHORITY

  公开号：WO2022082312A1

  公开（公告）日：2022-04-28

  The present disclosure relates to peptidic compounds of Formula A, A-II, A-III, B, or C, or salt or solvate thereof, compositions thereof, and methods of use thereof. The compounds of the present disclosure are useful for targeting CXCR4 for purposes such as imaging and/or therapeutics.

  本公开涉及A，A-II，A-III，B或C的肽化合物，或其盐或溶剂，以及其组合物和使用方法。本公开的化合物可用于针对CXCR4进行成像和/或治疗等目的。
• Targeted conformationally-constrained kinked endosomal disrupting peptides
  申请人：The University of Kansas

  公开号：US10766928B2

  公开（公告）日：2020-09-08

  A peptide can have a sequence of one of SEQ ID NOs: 78-91. A conformationally-constrained kinked peptide includes: a conformationally-constraining portion and a kinked portion linked to the conformationally-constraining portion that conformationally constrains the kinked portion having a peptide sequence of one of SEQ NOs: 78-97. A cell-targeting compound can include a conformationally-constrained kinked peptide having a peptide sequence of one of SEQ ID NOs: 78-97. The peptide sequence can be one of SEQ ID NOs: 78-97, or 78-91, or 92-97. A cell-targeting compound can include a conformationally-constrained kinked peptide linked to a branched linker with one branch arm linked to a specific targeting moiety and one branch arm linked to a general targeting moiety. The specific targeting moiety can be an antibody. The general targeting moiety can be a lipid or cholesterol derivative.

  多肽可以具有 SEQ ID NOs: 78-91 中的一个序列。构象约束扭结肽包括：构象约束部分和与构象约束部分相连的扭结部分，构象约束扭结部分具有 SEQ ID NOs: 78-97 之一的肽序列。细胞靶向化合物可包括具有 SEQ ID NOs: 78-97 之一肽序列的构象受限扭结肽。肽序列可以是 SEQ ID NOs：78-97、78-91 或 92-97 中的一种。细胞靶向化合物可包括与支链连接的构象受限扭结肽，其一个支臂与特异性靶向分子连接，一个支臂与一般靶向分子连接。特异性靶向分子可以是抗体。一般靶向分子可以是脂质或胆固醇衍生物。
• TARGETED CONFORMATIONALLY-CONSTRAINED KINKED ENDOSOMAL DISRUPTING PEPTIDES
  申请人：The University of Kansas

  公开号：US20170218022A1

  公开（公告）日：2017-08-03

  A peptide can have a sequence of one of SEQ ID NOs: 78-91. A conformationally-constrained kinked peptide includes: a conformationally-constraining portion and a kinked portion linked to the conformationally-constraining portion that conformationally constrains the kinked portion having a peptide sequence of one of SEQ NOs: 78-97. A cell-targeting compound can include a conformationally-constrained kinked peptide having a peptide sequence of one of SEQ ID NOs: 78-97. The peptide sequence can be one of SEQ ID NOs: 78-97, or 78-91, or 92-97. A cell-targeting compound can include a conformationally-constrained kinked peptide linked to a branched linker with one branch arm linked to a specific targeting moiety and one branch ann linked to a general targeting moiety. The specific targeting moiety can be an antibody. The general targeting moiety can be a lipid or cholesterol derivative.
• US9701715B2
  申请人：——

  公开号：US9701715B2

  公开（公告）日：2017-07-11