tert-butyl (4S)-3-(hydroxyamino)-4-methyl-2-oxohexanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: tert-butyl (4S)-3-(hydroxyamino)-4-methyl-2-oxohexanoate
• 化学式: C₁₁H₂₁NO₄
• 分子量: 231.29
• InChiKey: RSFREYWGCKSPSA-JAMMHHFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• AMIDE DERIVATIVES OF ANILINE-RELATED COMPOUNDS AND COMPOSITIONS THEREOF
  申请人：C&C BIOPHARMA, LLC

  公开号：US20150284360A1

  公开（公告）日：2015-10-08

  Amide derivatives of aniline-related compounds are disclosed, including salts thereof, and compositions, preparations and uses thereof. In certain embodiments, the amide derivatives and/or salts thereof show higher solubility in water compared to the corresponding parent aniline-related compounds.

  氨基苯酰衍生物的衍生物被披露，包括其盐，以及它们的组合物、制剂和用途。在某些实施例中，这些氨基苯酰衍生物和/或其盐与相应的母体氨基苯酰相关化合物相比在水中显示出更高的溶解度。
• CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS
  申请人：Hangzhou Dac Biotech Co., Ltd

  公开号：EP3210627A1

  公开（公告）日：2017-08-30

  A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a formula (I), wherein T, L, m, n, Y, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, and R13 are defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.

  强效细胞毒剂与细胞表面受体结合分子的共轭物具有式（I），其中 T、L、m、n、Y、R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R12 和 R13 在本文中定义，可用于癌症、自身免疫性疾病和传染病的靶向治疗。
• COMPOSITIONS AND METHODS FOR INCREASING TELOMERASE ACTIVITY
  申请人：HARLEY Calvin Bruce

  公开号：US20140088055A1

  公开（公告）日：2014-03-27

  The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
• US9403866B2
  申请人：——

  公开号：US9403866B2

  公开（公告）日：2016-08-02