4-[Di(butanoyloxy)methoxy]-4-oxobutanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-[Di(butanoyloxy)methoxy]-4-oxobutanoic acid
• 英文别名: 4-[di(butanoyloxy)methoxy]-4-oxobutanoic acid
• 化学式: C₁₃H₂₀O₈
• 分子量: 304.29
• InChiKey: PYBBPIBCPCZRAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  21
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  116
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] NOVEL CELL-PERMEABLE SUCCINATE COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS DE SUCCINATE PERMÉABLES À TRAVERS LES CELLULES
  申请人：NEUROVIVE PHARMACEUTICAL AB

  公开号：WO2015155231A1

  公开（公告）日：2015-10-15

  The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates from mitochondrial oxidative phosphorylation, a process to which high-energy electrons are provided by the Kreb's cycle. Not all Kreb's cycle intermediates are readily permeable to the cellular membrane, one of them being succinate. The provision of the novel cell permeable succinates is envisaged to allow passage over the cellular membrane and thus the cell permeable succinates can be used to enhance mitochondrial ATP-output.

  本发明提供了新型的细胞可渗透琥珀酸盐和琥珀酸盐的细胞可渗透前体，旨在增加线粒体中的ATP产生。在真核细胞中产生和利用的大部分ATP源自线粒体氧化磷酸化，这是一个高能电子由克雷布氏循环提供的过程。并非所有克雷布氏循环中间体都能轻易渗透到细胞膜，其中之一就是琥珀酸盐。提供新型的细胞可渗透琥珀酸盐可让其通过细胞膜，因此细胞可渗透琥珀酸盐可用于增强线粒体的ATP产出。
• PROTECTED SUCCINATES FOR ENHANCING MITOCHONDRIAL ATP-PRODUCTION
  申请人：MITOPHARM LTD

  公开号：US20150259317A1

  公开（公告）日：2015-09-17

  Disclosed herein are mono or di-succinate compounds where one or both of the acid groups in the succinate core are protected in the form of biologically labile moieties, and the use of said compounds to enhance mitochondrial function. The compounds may be of formula (I) wherein R 1 is H or an optionally substituted alkyl group or a group of formula (II) and R 2 is independently a group according to formula (II) where formula (II) is as defined 10 herein.

  本文揭示了一种单或二琥珀酸酯化合物，其中琥珀酸核中的一个或两个酸基以生物活性的基团形式得到保护，并且使用该化合物来增强线粒体功能。该化合物可以是式（I）的形式，其中R1为H或可选择取代的烷基或式（II）的基团，R2独立地是式（II）定义的基团，其中式（II）如本文所定义。
• Cell-permeable succinate compounds
  申请人：NEUROVIVE PHARMACEUTICAL AB

  公开号：US11147789B2

  公开（公告）日：2021-10-19

  The present invention provides novel cell-permeable succinates and cell permeable precursors of succinateaimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates from mitochondrial oxidative phosphorylation, a process to which high-energy electrons are provided by the Kreb's cycle. Not all Kreb's cycle intermediates are readily permeable to the cellular membrane, one of them being succinate. The provision of the novel cell permeable succinates is envisaged to allow passage over the cellular membrane and thus the cell permeable succinates can be used to enhance mitochondrial ATP-output.

  本发明提供了新型细胞渗透性琥珀酸盐和细胞渗透性琥珀酸盐前体，旨在增加线粒体中的 ATP 生成。真核细胞中产生和利用的 ATP 主要来自线粒体氧化磷酸化，这一过程由克雷伯循环提供高能电子。并非所有的克雷伯循环中间产物都能轻易渗透到细胞膜中，琥珀酸就是其中之一。设想提供新型细胞渗透性琥珀酸盐可使其通过细胞膜，因此细胞渗透性琥珀酸盐可用于提高线粒体 ATP 的输出。
• NOVEL CELL-PERMEABLE SUCCINATE COMPOUNDS
  申请人：Neurovive Pharmaceutical AB

  公开号：EP3129016A1

  公开（公告）日：2017-02-15
• PRODRUGS OF SUCCINIC ACID FOR INCREASING ATP PRODUCTION
  申请人：Neurovive Pharmaceutical AB

  公开号：EP3129364A1

  公开（公告）日：2017-02-15