Bis(2-propanoyloxyethyl) butanedioate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Bis(2-propanoyloxyethyl) butanedioate
• 英文别名: bis(2-propanoyloxyethyl) butanedioate
• 化学式: C₁₄H₂₂O₈
• 分子量: 318.32
• InChiKey: BUTQERSOJZNLSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• PROTECTED SUCCINATES FOR ENHANCING MITOCHONDRIAL ATP-PRODUCTION
  申请人：Mitopharm Ltd.

  公开号：EP2903609A1

  公开（公告）日：2015-08-12
• SUCCINATE PRODRUGS FOR USE IN THE TREATMENT OF LACTIC ACIDOSIS OR DRUG-INDUCED SIDE-EFFECTS DUE TO COMPLEX I-RELATED IMPAIRMENT OF MITOCHONDRIAL OXIDATIVE PHOSPHORYLATION
  申请人：Neurovive Pharmaceutical AB

  公开号：EP3129058A1

  公开（公告）日：2017-02-15
• [EN] PROTECTED SUCCINATES FOR ENHANCING MITOCHONDRIAL ATP-PRODUCTION<br/>[FR] SUCCINATES PROTÉGÉS POUR ACCROÎTRE LA PRODUCTION MITOCHONDRIALE D'ATP
  申请人：MITOPHARM LTD

  公开号：WO2014053857A1

  公开（公告）日：2014-04-10

  Disclosed herein are mono or di-succinate compounds where one or both of the acid groups in the succinate core are protected in the form of biologically labile moieties, and the use of said compounds to enhance mitochondrial function. The compounds may be of formula (I) wherein R1 is H or an optionally substituted alkyl group or a group of formula (II) and R2 is independently a group according to formula (II) where formula (II) is as defined 10 herein.
• [EN] SUCCINATE PRODRUGS FOR USE IN THE TREATMENT OF LACTIC ACIDOSIS OR DRUG-INDUCED SIDE-EFFECTS DUE TO COMPLEX I-RELATED IMPAIRMENT OF MITOCHONDRIAL OXIDATIVE PHOSPHORYLATION<br/>[FR] PROMÉDICAMENTS À BASE DE SUCCINATE DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE L'ACIDOSE LACTIQUE OU D'EFFETS SECONDAIRES INDUITS PAR UN MÉDICAMENT DUS À UNE DÉFICIENCE LIÉE AU COMPLEXE I DE LA PHOSPHORYLATION OXYDATIVE MITOCHONDRIALE
  申请人：NEUROVIVE PHARMACEUTICAL AB

  公开号：WO2015155238A1

  公开（公告）日：2015-10-15

  The present invention relates to a succinate prodrug for use in the treatment or prevention of lactic acidosis.