3-(4-Fluorophenyl)-7-[(4-fluorophenyl)methylidene]-2,5-dimethyl-3,3a,4,6-tetrahydropyrazolo[4,3-c]pyridine | 494785-39-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4-Fluorophenyl)-7-[(4-fluorophenyl)methylidene]-2,5-dimethyl-3,3a,4,6-tetrahydropyrazolo[4,3-c]pyridine
• 英文别名: 3-(4-fluorophenyl)-7-[(4-fluorophenyl)methylidene]-2,5-dimethyl-3,3a,4,6-tetrahydropyrazolo[4,3-c]pyridine
• CAS: 494785-39-6
• 化学式: C₂₁H₂₁F₂N₃
• 分子量: 353.415
• InChiKey: HQRADAGJSNDTOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  18.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,5-bis-(4-fluoro-benzylidene)-1-methyl-piperidin-4-one 、 甲基肼 在 MCM-41-embedded α-iron(III) oxide 作用下， 以 乙醇 为溶剂， 反应 0.17h， 以98%的产率得到3-(4-Fluorophenyl)-7-[(4-fluorophenyl)methylidene]-2,5-dimethyl-3,3a,4,6-tetrahydropyrazolo[4,3-c]pyridine
  参考文献：
  名称：

  (α-Fe2O3)-MCM-41 as a magnetically recoverable nanocatalyst for the synthesis of pyrazolo[4,3-c]pyridines at room temperature

  摘要：

  MCM-41 embedded magnetic nanoparticles which was prepared through the formation of MCM-41 in the presence of Fe3O4 nanoparticles has been used as a magnetically recoverable catalyst for the synthesis of new series of pyrazolo[3,4-c]pyridine derivatives. This catalyst with 10 wt.% of loaded iron oxide nanoparticles was highly recyclable (up to 5 times), and was easily recovered from the reaction mixture using an external magnet without loss of activity. The prepared magnetic catalyst is characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR), nitrogen physisorption measurements, and acid-base titration. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.catcom.2012.05.022

文献信息

• (α-Fe2O3)-MCM-41 as a magnetically recoverable nanocatalyst for the synthesis of pyrazolo[4,3-c]pyridines at room temperature
  作者：Shahnaz Rostamizadeh、Nasrin Shadjou、Mohammad Azad、Nima Jalali

  DOI：10.1016/j.catcom.2012.05.022

  日期：2012.9

  MCM-41 embedded magnetic nanoparticles which was prepared through the formation of MCM-41 in the presence of Fe3O4 nanoparticles has been used as a magnetically recoverable catalyst for the synthesis of new series of pyrazolo[3,4-c]pyridine derivatives. This catalyst with 10 wt.% of loaded iron oxide nanoparticles was highly recyclable (up to 5 times), and was easily recovered from the reaction mixture using an external magnet without loss of activity. The prepared magnetic catalyst is characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR), nitrogen physisorption measurements, and acid-base titration. (C) 2012 Elsevier B.V. All rights reserved.