2-methylamino-5-nitro-benzaldehyde | 50609-41-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methylamino-5-nitro-benzaldehyde
• 英文别名: 2-(Methylamino)-5-nitrobenzaldehyde
• CAS: 50609-41-1
• 化学式: C₈H₈N₂O₃
• 分子量: 180.163
• InChiKey: ZBCLFZLRLKHLMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-methylamino-5-nitro-benzaldehyde 、 2-氨基苯甲酰胺 在 对甲苯磺酸 作用下， 以 乙醇 为溶剂， 反应 1.5h， 生成
  参考文献：
  名称：

  Efficient synthesis and fluorescence properties of highly functionalized 2-aryl-quinazolin-4(3H)-ones

  摘要：

  Three different methodologies for the preparation of highly substituted 2-aryl-quinazolin-4(3H)-ones including short and high-yielding reaction sequences are described. The 2-aryl-substituent of most of the target compounds bears three functional groups. The fluorescence properties of these compounds are presented and potential correlations between structure and optical properties are discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.139
• 作为产物：
  描述：

  2-氟-5-硝基苯甲醛 、 甲胺 以 乙醇 、 二甲基亚砜 为溶剂， 反应 12.0h， 以99%的产率得到2-methylamino-5-nitro-benzaldehyde
  参考文献：
  名称：

  Efficient synthesis and fluorescence properties of highly functionalized 2-aryl-quinazolin-4(3H)-ones

  摘要：

  Three different methodologies for the preparation of highly substituted 2-aryl-quinazolin-4(3H)-ones including short and high-yielding reaction sequences are described. The 2-aryl-substituent of most of the target compounds bears three functional groups. The fluorescence properties of these compounds are presented and potential correlations between structure and optical properties are discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.139

文献信息

• WILSHIRE, J. F. K., AUSTRAL. J. CHEM., 1982, 35, N 12, 2497-2504
  作者：WILSHIRE, J. F. K.

  DOI：——

  日期：——
• Efficient synthesis and fluorescence properties of highly functionalized 2-aryl-quinazolin-4(3H)-ones
  作者：Michael Waibel、Jens Hasserodt

  DOI：10.1016/j.tetlet.2009.03.139

  日期：2009.6

  Three different methodologies for the preparation of highly substituted 2-aryl-quinazolin-4(3H)-ones including short and high-yielding reaction sequences are described. The 2-aryl-substituent of most of the target compounds bears three functional groups. The fluorescence properties of these compounds are presented and potential correlations between structure and optical properties are discussed. (C) 2009 Elsevier Ltd. All rights reserved.