[2-(2-Acetamido-4-amino-1,3-dioxoinden-2-yl)-5-propan-2-ylphenyl] butyl carbonate;dibutyl carbonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: [2-(2-Acetamido-4-amino-1,3-dioxoinden-2-yl)-5-propan-2-ylphenyl] butyl carbonate;dibutyl carbonate
• 英文别名: [2-(2-acetamido-4-amino-1,3-dioxoinden-2-yl)-5-propan-2-ylphenyl] butyl carbonate;dibutyl carbonate
• 化学式: C34H46N2O9
• 分子量: 626.7
• InChiKey: LBJBFRYZGBKWAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.86
• 重原子数：
  45
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  160
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• 1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT
  申请人：Korea Research Institute of Chemical Technology

  公开号：EP2722322A2

  公开（公告）日：2014-04-23

  The present invention relates to 1,3-dioxoindene derivatives, pharmaceutically acceptable salts or optical isomers thereof, a preparation method for same, and a pharmaceutical composition containing same as an active ingredient with antiviral activity. The 1,3-dioxoindene derivatives of formula (1) according to the present invention have low cyto-toxicity, and can also demonstrate utility as pharmaceutical compositions for preventing or treating viral diseases such as:; polio, viral paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-mouth disease, blistering diseases, hepatitis A, myositis, myocarditis, pancreatitis, viral diabetes, epidemic myalgia, encephalitis, flu, herpes angina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis, otitis media, and the like, since excellent antiviral activity against picornaviruses such as Coxsackie virus, enterovirus, echovirus, polio virus, rhinovirus, and the like, have been demonstrated.

  本发明涉及具有抗病毒活性的 1，3-二氧代茚衍生物、其药学上可接受的盐或光学异构体、其制备方法以及含有其作为活性成分的药物组合物。根据本发明，式（1）的 1，3-二氧代茚衍生物具有低细胞毒性，还可作为药物组合物用于预防或治疗病毒性疾病，如：：;脊髓灰质炎、病毒性麻痹、急性出血性结膜炎、病毒性脑膜炎、手足口病、大疱病、甲型肝炎、肌炎、心肌炎、胰腺炎、病毒性糖尿病、流行性肌痛、脑炎、流感、疱疹性心绞痛、口蹄疫、哮喘、慢性阻塞性肺病、肺炎、鼻窦炎、中耳炎等，因为对柯萨奇病毒、肠道病毒、埃可病毒、脊髓灰质炎病毒、鼻病毒等皮卡病毒有很好的抗病毒活性。