butyl N-[1-(cyclopentylamino)-1-oxopropan-2-yl]carbamate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: butyl N-[1-(cyclopentylamino)-1-oxopropan-2-yl]carbamate
• 化学式: C₁₃H₂₄N₂O₃
• 分子量: 256.34
• InChiKey: GRJIIGWIATVQPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] HETEROCYCLE-BISAMIDE INHIBITORS OF SCAVENGER RECEPTOR BL<br/>[FR] INHIBITEURS HÉTÉROCYCLE - BISAMIDE DE RÉCEPTEUR ÉBOUEUR BL
  申请人：BROAD INST INC

  公开号：WO2014063168A1

  公开（公告）日：2014-04-24

  This appl ication describes compounds and methods that can inhibit Scavenger receptor class B, type I (SR-BI) activity, wh ich compounds and methods can be used, for example, to med iate h igh-density l ipoprotein (H DL) l ipid uptake and treat hepatitis C vira l infections. The compounds have the formu la : wherein R1 and R2 are independently H, halogen, cyano, haloalkyl, ha loa lkyloxy or OMe; or R1 and R2 together are -O-CH2-O- or -0- CF2-O-; R3 is H, ha logen, cyano, ha loalkyl or ha loa lkyloxy; R4 is C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkylmethyl or C3-6cycloheteroalkyl, wherein the heteroatom is N or 0; R5 is H or CH3; R6 is C1-6alkyl or C3-6cycloalkyl; and A, B, D and E are each, independently, CH, N, 0 or S, wherein at least one of A, B, D and E is N, and another of A, B, D and E is N, 0 or S.