(2S)-2-amino-3-methylbutanoic acid;1-hydroxyquinolin-2-one

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-amino-3-methylbutanoic acid;1-hydroxyquinolin-2-one
• 化学式: C14H18N2O4
• 分子量: 278.3
• InChiKey: YDOUVEVPJOWFQP-VWMHFEHESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.29
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• EP2909189A1
  申请人：——

  公开号：EP2909189A1

  公开（公告）日：2015-08-26
• HETEROARYL LINKED QUINOLINYL MODULATORS OF RORYT
  申请人：Janssen Pharmaceutica N.V.

  公开号：EP3083561A1

  公开（公告）日：2016-10-26
• [EN] HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt<br/>[FR] MODULATEURS DE RORYT DE TYPE QUINOLINYLE À LIAISON HÉTÉROARYLE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2014062655A1

  公开（公告）日：2014-04-24

  The present invention comprises compounds of Formula I. Wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.
• [EN] HETEROARYL LINKED QUINOLINYL MODULATORS OF RORϒT<br/>[FR] MODULATEURS DE RORYT PORTANT UN GROUPE QUINOLYLE LIÉ À UN GROUPE HÉTÉROARYLE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2015057200A1

  公开（公告）日：2015-04-23

  The present invention comprises compounds of Formula I wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification, The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORϒt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.