(S)-2-(1'-acetyl-2-oxospiro[indoline-3,2'-piperidine]-1-yl)-N-methylacetamide | 1236108-12-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-(1'-acetyl-2-oxospiro[indoline-3,2'-piperidine]-1-yl)-N-methylacetamide
• 英文别名: 2-[(3S)-1'-acetyl-2-oxospiro[indole-3,2'-piperidine]-1-yl]-N-methylacetamide
• CAS: 1236108-12-5
• 化学式: C₁₇H₂₁N₃O₃
• 分子量: 315.372
• InChiKey: NHIKEWGMUNWFOD-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  69.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (S)-methyl 2-(1'-acetyl-2-oxospiro[indoline-3,2'-piperidine]-1-yl)acetate 、 甲胺 以 乙醇 为溶剂， 以93%的产率得到(S)-2-(1'-acetyl-2-oxospiro[indoline-3,2'-piperidine]-1-yl)-N-methylacetamide
  参考文献：
  名称：

  The spiropiperidine-3,3′-oxindole scaffold: a type II β-turn peptide isostere

  摘要：

  An unprecedented chiral spiropiperidine oxindole system quaternary 3-aminooxindole and relying on a ring closing acts as an highly constrained Freidinger gamma-lactam, adopting assessed by modelling and spectroscopical studies. was synthesized starting from enantiopure metathesis as the key step. This compound a type II beta-turn conformation in solution, as (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.04.077

文献信息

• The spiropiperidine-3,3′-oxindole scaffold: a type II β-turn peptide isostere
  作者：Giordano Lesma、Nicola Landoni、Alessandro Sacchetti、Alessandra Silvani

  DOI：10.1016/j.tet.2010.04.077

  日期：2010.6

  An unprecedented chiral spiropiperidine oxindole system quaternary 3-aminooxindole and relying on a ring closing acts as an highly constrained Freidinger gamma-lactam, adopting assessed by modelling and spectroscopical studies. was synthesized starting from enantiopure metathesis as the key step. This compound a type II beta-turn conformation in solution, as (C) 2010 Elsevier Ltd. All rights reserved.