ethyl N-[7-[ethoxycarbonyl(2-methylprop-2-enyl)amino]-2,3-dimethylheptan-2-yl]-N-(2-methylprop-2-enyl)carbamate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl N-[7-[ethoxycarbonyl(2-methylprop-2-enyl)amino]-2,3-dimethylheptan-2-yl]-N-(2-methylprop-2-enyl)carbamate
• 化学式: C₂₃H₄₂N₂O₄
• 分子量: 410.6
• InChiKey: STFZVVZUFXLOQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  29
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• DENTAL RESTORATIVE MATERIAL
  申请人：Tokuyama Dental Corporation

  公开号：EP2724706A1

  公开（公告）日：2014-04-30

  The present invention discloses a dental restorative material comprising 10-50 mass% of (A) a polymerizable monomer, 5-80 mass% of (B)an organic-inorganic composite filler which is prepared by dispersing an inorganic fine filler having an average particle diameter of 1 µm or smaller in an organic matrix and has an average particle diameter of 5.0-50 µm, and 10-60 mass% of (C) a third component, i.e., an inorganic filler having an average particle diameter of 1.1-5.0 µm, wherein the absolute value of the difference between the refractive index [nC] of the inorganic filler (C) and the refractive index [nB] of the organic-inorganic composite filler (B)(i.e., |nC-nB|) is 0.005-0.07 at 32°C and the absolute value of the difference between the refractive index [nA] of the cured product of the polymerizable monomer (A) and the refractive index [nC] of the inorganic filler (C) (i.e., |nA-nC|) is 0.005-0.05 at 32°C.

  本发明公开了一种牙科修复材料，包括 10-50 质量％的(A)可聚合单体、5-80 质量％的(B)有机-无机复合填料，该填料是通过在有机基质中分散平均颗粒直径为 1 微米或更小的无机精细填料制备而成，其平均颗粒直径为 5.0-50 微米；以及 10-60 质量％的(C)第三组分，即平均颗粒直径为 1.1-5.0 微米的无机填料、其中无机填料 (C) 的折射率[nC]与有机-无机复合填料 (B) 的折射率[nB]之差的绝对值（即、在 32°C 时，|nC-nB|）的绝对值为 0.005-0.07；在 32°C 时，可聚合单体（A）固化产物的折射率[nA]与无机填料（C）的折射率[nC]之差（即|nA-nC|）的绝对值为 0.005-0.05。
• DENTAL FILLING AND RESTORATIVE MATERIAL KIT
  申请人：Tokuyama Dental Corporation

  公开号：EP2977040A1

  公开（公告）日：2016-01-27

  To allow the restoration of a tooth to be performed with satisfactory color tone conformability and little reduction in lightness, thus enabling restoration with high aesthetics, in particular, to allow even the characteristic structure of dentin to be reproduced even in a cavity in which a background color tone can be seen through, provided is a dental filling and restorative material kit, including: a polymerizable composition (A) for a dentin restorative material for restoring a dentin portion; and a polymerizable composition (B) for an enamel restorative material to be layered on the dentin restorative material, in which the polymerizable composition (A) for a dentin restorative material and the polymerizable composition (B) for an enamel restorative material have different color tones, and in which a difference (nDa-nDb) between a refractive index nD3 of a polymer of a polymerizable monomer (a) in the polymerizable composition (A) for a dentin restorative material and a refractive index nDb of a polymer of a polymerizable monomer (b) in the polymerizable composition (B) for an enamel restorative material is 0.005 or more.

  为了使牙齿的修复具有令人满意的色调顺应性和较小的亮度降低，从而使修复具有较高的美观性，特别是在背景色调可以被看穿的牙洞中也能再现牙本质的特征结构，提供了一种牙科填充和修复材料套件，包括用于修复牙本质部分的牙本质修复材料的可聚合组合物 (A)；以及用于在牙本质修复材料上分层的釉质修复材料的可聚合组合物（B），其中用于牙本质修复材料的可聚合组合物（A）和用于釉质修复材料的可聚合组合物（B）具有不同的色调、其中用于牙本质修复材料的可聚合组合物（A）中可聚合单体（a）的聚合物的折射率 nD3 与用于珐琅质修复材料的可聚合组合物（B）中可聚合单体（b）的聚合物的折射率 nDb 之差（nDa-nDb）为 0.005 或更高。
• CURABLE COMPOSITION AND DENTAL FILLING RESTORATIVE MATERIAL
  申请人：Tokuyama Dental Corporation

  公开号：EP3366269A1

  公开（公告）日：2018-08-29

  Provided is a curable composition having excellent cavity restoration workability as well as an appearance of the resulting cured article that matches the natural teeth and continues to match the natural teeth. A curable composition including a polymerizable monomer component (A), a spherical filler (B) having an average particle size within the range of 230-1000 nm, and a polymerization initiator (C), wherein the curable composition is characterized by having a value (V) of less than 5 and a chroma (C) of 0.05 or higher in colorimetric values according to the Munsell Color System in colored light on a black background, and a value (V) of 6 or higher and a chroma (C) of less than 2 in colorimetric values according to the Munsell Color System in colored light on a white background, each of the values (V) and chroma (C) being measured using a color difference meter in a state in which a 1-mm-thick cured article has been formed.

  本发明提供了一种可固化组合物，该组合物具有极佳的龋洞修复可加工性，且固化后的制品外观与天然牙齿相匹配，并可持续与天然牙齿相匹配。一种可固化组合物，包括可聚合单体组分 (A)、平均粒径在 230-1000 纳米范围内的球形填料 (B) 和聚合引发剂 (C)，其中可固化组合物的特征在于，根据色度值 (V) 小于 5 和色度 (C) 在 0.根据蒙赛尔色彩系统，在黑色背景上的色光中，色度值（V）小于 5，色度（C）大于或等于 0.05；根据蒙赛尔色彩系统，在白色背景上的色光中，色度值（V）大于或等于 6，色度（C）小于 2。
• PHOTOPOLYMERIZATION INITIATOR AND PHOTOCURABLE COMPOSITION
  申请人：Tokuyama Dental Corporation

  公开号：EP3427716A1

  公开（公告）日：2019-01-16

  A photopolymerization initiator including (a) a photosensitizer, (b) a tertiary amine compound and (c) an aryliodonium salt wherein, as the aryliodonium salt (c), there is selected the one that generates an acid having a dissociation constant of not less than -3.0 in water of 25°C.

  一种光聚合引发剂，包括(a)一种光敏剂，(b)一种叔胺化合物和(c)一种芳基碘鎓盐，其中，作为芳基碘鎓盐(c)，选择在 25°C 水中生成解离常数不小于-3.0 的酸的一种。
• PHOTOCURABLE COMPOSITION
  申请人：Tokuyama Dental Corporation

  公开号：EP3508190A1

  公开（公告）日：2019-07-10

  According to the present invention, a photocurable composition is provided, which is characterized by comprising a polymerizable monomer component (A), an inorganic filler component (B) having an average particle diameter of 0.07 µm or more, an organic-inorganic composite filler component (C) comprising an inorganic filler component (C1) and an organic polymer component (C2) and having an average particle diameter of 0.5 µm or more, and a photopolymerization initiator (D), wherein the inorganic filler component (B) and the organic-inorganic composite filler component (C) are contained in a total amount of 100 to 1500 parts by mass relative to 100 parts by mass of the polymerizable monomer component (A), and the polymerizable monomer component (A), 90 parts by mass or more of the inorganic filler component (B) and 90 parts by mass or more of the organic-inorganic composite filler component (C) are selected in such a manner that specific requirements can be satisfied.

  根据本发明，提供了一种光固化组合物，其特征在于包括可聚合单体组分 (A)、平均颗粒直径大于或等于 0.07 µm 的无机填料组分 (B)、由无机填料组分 (C1) 和有机聚合物组分 (C2) 组成且平均颗粒直径大于或等于 0.5 µm 或更大，以及光聚合引发剂 (D)，其中无机填料组分 (B) 和有机-无机复合填料组分 (C) 的总含量相对于 100 质量份的可聚合单体组分 (A) 为 100 至 1500 质量份、可聚合单体组分（A）、无机填料组分（B）和有机-无机复合填料组分（C）的质量份数分别为 90 份或以上，以满足特定要求。