N-carboxysarcosine anhydride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-carboxysarcosine anhydride
• 英文别名: [2-[2-[carboxy(methyl)amino]acetyl]oxy-2-oxoethyl]-methylcarbamic acid
• 化学式: C₈H₁₂N₂O₇
• 分子量: 248.19
• InChiKey: RNCUVGZFNHRFPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• BRANCHED AMPHIPATHIC BLOCK POLYMER AND MOLECULAR AGGREGATE AND DRUG DELIVERY SYSTEM USING SAME
  申请人：Ozeki Eiichi

  公开号：US20140127132A1

  公开（公告）日：2014-05-08

  Provided is a polymeric micelle pharmaceutical preparation that can increase the ratio of contrast at tumor site to background contrast in a short period of time after administration of a lactosome and can suppress the ABC phenomenon so that the lactosome can be administered more than once within a short span. A branched-type amphiphilic block polymer comprising: a multi-branched hydrophilic block comprising sarcosine; and a hydrophobic block comprising polylactic acid. The branched-type amphiphilic block polymer, wherein the number of branches of the hydrophilic block is 3. A molecular assembly comprising the branched-type amphiphilic block polymer. The molecular assembly further comprising a linear type amphiphilic block polymer.

  提供的是一种聚合物胶束制药制剂，可以在给予乳状体后的短时间内增加肿瘤部位与背景对比的比例，并且可以抑制ABC现象，使得乳状体可以在短时间内多次给药。包括以下部分的分支型两性块聚合物：包括硫氨酸的多支链亲水块；和包括聚乳酸的疏水块。该分支型两性块聚合物，其中亲水块的支链数为3。包括该分支型两性块聚合物的分子组装体。该分子组装体进一步包括线型两性块聚合物。
• PROCESS FOR PRODUCING NANOPARTICLES
  申请人：Shimadzu Corporation

  公开号：EP3127943A1

  公开（公告）日：2017-02-08

  Provided is a method for producing a nanoparticle having a uniform particle diameter. A method for producing a nanoparticle comprising an amphiphilic block polymer, the method comprising: with use of a nanoparticle production device that includes: a polymer solution supply channel Cp; an aqueous liquid supply channel Cw1, Cw2; a junction J of the channels; a nanoparticle formation channel Cn; and a nanoparticle-containing liquid outlet On, supplying a solution of a polymer and an aqueous liquid to the junction J; forming a nanoparticle while bringing a laminar flow of the polymer solution and a laminar flow of the aqueous liquid into contact with each other; obtaining a liquid containing the formed nanoparticle from the nanoparticle-containing liquid outlet; and controlling a particle diameter of the nanoparticle by measuring a statistic of the particle diameter of the formed nanoparticle in real time, and by controlling at least one of an amount of the polymer solution supplied to the junction and an amount of the aqueous liquid supplied to the junction such that the statistic becomes a desired value.

  提供了一种生产具有均匀粒径的纳米粒子的方法。一种生产包含两性嵌段聚合物的纳米粒子的方法，该方法包括：使用纳米粒子生产装置，该装置包括聚合物溶液供应通道 Cp；水性液体供应通道 Cw1、Cw2；通道的交界处 J；纳米粒子形成通道 Cn；以及含纳米粒子液体出口 On，向交界处 J 供应聚合物溶液和水性液体；形成纳米粒子，同时使聚合物溶液的层流和水性液体的层流相互接触；从含有纳米颗粒的液体出口获得含有已形成的纳米颗粒的液体；以及 通过实时测量已形成的纳米颗粒的颗粒直径的统计量，并通过控制提供给接合点的聚合物溶液的量和提供给接合点的水性液体的量中的至少一个量来控制纳米颗粒的颗粒直径，从而使统计量达到所需的值。
• METHOD FOR PRODUCING MOLECULAR ASSEMBLIES, AND DEVICE FOR PRODUCING MOLECULAR ASSEMBLIES
  申请人：Shimadzu Corporation

  公开号：EP3231832A1

  公开（公告）日：2017-10-18

  The present invention relates to a method and an apparatus both for producing molecular assemblies of an amphiphilic block polymer. The method of the present invention includes: applying a polymer solution (45) containing an amphiphilic block polymer and a solvent in a layered shape on a planar base member (11) in a film forming part (40); forming a polymer film on the base member (13) by removing the solvent from the coated layer of the solution in a drying part (30); and producing molecular assemblies by bringing the polymer film into contact with a water-based liquid (55) in a molecular assembly forming part (50). The amphiphilic block polymer has a hydrophilic block chain and a hydrophobic block chain. The hydrophilic block chain preferably has 20 or more sarcosine units, and the hydrophobic block chain preferably has 10 or more lactic acid units.

  本发明涉及一种生产两性嵌段聚合物分子组装体的方法和设备。本发明的方法包括：在成膜部件（40）中将含有两亲性嵌段聚合物和溶剂的聚合物溶液（45）分层涂覆在平面基座部件（11）上；在干燥部件（30）中通过从溶液涂覆层中除去溶剂在基座部件（13）上形成聚合物膜；以及在分子组装体形成部件（50）中通过使聚合物膜与水基液体（55）接触生产分子组装体。两亲嵌段聚合物具有亲水嵌段链和疏水嵌段链。亲水嵌段链最好有 20 个或更多肌氨酸单元，疏水嵌段链最好有 10 个或更多乳酸单元。
• Manufacturing method for nanoparticle
  申请人：SHIMADZU CORPORATION

  公开号：US10035887B2

  公开（公告）日：2018-07-31

  A manufacturing method for nanoparticles including an amphiphilic block polymer having a uniform particle diameters has steps of forming a laminar flow of polymer solution by inducing a solution comprising an amphiphilic block polymer having a hydrophilic block and a hydrophobic block in an organic solvent into a polymer solution supply flow passage, a step of forming at least two laminar flows of a water system solution by inducing the water system solution to at least two water system solution supply passages, and a step of forming nanoparticles comprising the amphiphilic block polymer by making a confluence as if at least two laminar flows of water system solution sandwich the laminar flow of the polymer solution.

  一种包括具有均匀颗粒直径的两性嵌段聚合物的纳米颗粒的制造方法，其步骤包括：通过将在有机溶剂中具有亲水嵌段和疏水嵌段的两性嵌段聚合物组成的溶液引入聚合物溶液供应流道，形成聚合物溶液的层流、通过将水系统溶液引入至少两个水系统溶液供应流道，形成至少两股水系统溶液层流的步骤，以及通过使至少两股水系统溶液层流夹在聚合物溶液层流中形成汇流，形成包含两性嵌段聚合物的纳米颗粒的步骤。
• MOLECULAR ASSEMBLY USING BRANCHED AMPHIPHILIC BLOCK POLYMER, AND DRUG TRANSPORTATION SYSTEM
  申请人：Shimadzu Corporation

  公开号：EP2893924B1

  公开（公告）日：2020-11-11