2-Amino-3-[[2-amino-3-[(2-methylpropan-2-yl)oxy]-3-oxopropyl]disulfanyl]propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-3-[[2-amino-3-[(2-methylpropan-2-yl)oxy]-3-oxopropyl]disulfanyl]propanoic acid
• 英文别名: 2-amino-3-[[2-amino-3-[(2-methylpropan-2-yl)oxy]-3-oxopropyl]disulfanyl]propanoic acid
• 化学式: C₁₀H₂₀N₂O₄S₂
• 分子量: 296.4
• InChiKey: LSWAVWCKURVBFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  166
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• [EN] PANTETHENOYLCYSTEINE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE PANTÉTHÉNOYLCYSTÉINE ET LEURS UTILISATIONS
  申请人：COMET THERAPEUTICS INC

  公开号：WO2020198573A1

  公开（公告）日：2020-10-01

  The present disclosure relates to compounds of Formula (I) or (II): (Formulae (I), (II)), and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions.

  本公开涉及式(I)或(II)的化合物：(式(I)，(II))，以及其药用可接受的盐或溶剂化合物。本公开还涉及包含这些化合物的药物组合物，以及这些化合物和药物组合物的治疗和诊断用途。
• [EN] MASP INHIBITORY COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS INHIBITEURS DE MASP ET LEURS UTILISATIONS
  申请人：BAYER AG

  公开号：WO2020225095A1

  公开（公告）日：2020-11-12

  The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.

  本发明涉及新型甘霖结合凝集素（MBL）相关丝氨酸蛋白酶（MASP）抑制化合物，以及其类似物和衍生物，以及其制备方法，单独或组合用于治疗和/或预防疾病，以及用于生产药物治疗和/或预防疾病，特别是用于治疗和/或预防肾脏和心血管疾病以及缺血再灌注损伤。
• [EN] CYCLIC PEPTIDE INHIBITORS OF HEDGEHOG PROTEINS<br/>[FR] INHIBITEURS PEPTIDIQUES CYCLIQUES DE PROTÉINES HEDGEHOG
  申请人：UNIV ROCHESTER

  公开号：WO2017223207A1

  公开（公告）日：2017-12-28

  Cyclic peptide compounds are provided that can bind to one or more homologs of Hedghehog signaling proteins and block their interaction with the Patched receptor. These compounds are useful for suppressing Hedgehog-dependent stimulation of the Hedgehog pathway in cells and in living organisms. Methods for using the cyclic peptide compounds, and compositions comprising them, for treatment of cancers and other diseases which are characterized by aberrant Hedgehog-dependent activation of the Hedgehog pathway and/or which can benefit from chemical suppression of Hedgehog-dependent signaling are also disclosed.

  本发明提供了可以结合一个或多个Hedghehog信号蛋白同源物并阻止它们与Patched受体相互作用的环肽化合物。这些化合物对于抑制细胞和生物体中Hedgehog通路的Hedgehog依赖性刺激非常有用。还公开了使用环肽化合物的方法和包含它们的组合物，用于治疗癌症和其他疾病，这些疾病的特征是Hedgehog通路的异常Hedgehog依赖性激活和/或可以受益于化学抑制Hedgehog依赖性信号。
• Compositions and methods for antibody production
  申请人：ImmunoGen, Inc.

  公开号：US10913795B2

  公开（公告）日：2021-02-09

  Compositions and methods for minimizing antibody disulfide bond reduction are described. In one aspect, a composition is provided for culturing mammalian host cells to express an antibody including an anti-reduction agent that minimizes reduction of a disulfide bond in the antibody or fragment thereof. In some other aspects, methods for minimizing disulfide bond reduction; increasing production of an antibody or fragment thereof with intact native disulfide bonds; increasing a ratio of non-reduced to reduced antibody or fragment thereof; producing a therapeutic antibody or fragment thereof by adding a sufficient amount of an anti-reduction agent to a cell culture media, pre-harvest cell culture fluid, or harvest cell culture fluid are described. In another aspect, minimizing disulfide bond reduction in an antibody or fragment thereof culturing the host cell in a concentration of at least about 20% O2 is described.

  本文描述了使抗体二硫键还原最小化的组合物和方法。在一个方面，提供了一种用于培养哺乳动物宿主细胞以表达抗体的组合物，该组合物包括一种抗还原剂，可最大程度地减少抗体或其片段中二硫键的还原。在其他一些方面，描述了使二硫键还原最小化的方法；提高具有完整原生二硫键的抗体或其片段的产量；提高非还原抗体或其片段与还原抗体或其片段的比例；通过向细胞培养基、收获前细胞培养液或收获细胞培养液中添加足量的抗还原剂来生产治疗性抗体或其片段。在另一个方面，描述了在至少约 20% 的氧气浓度下培养宿主细胞可最大程度地减少抗体或其片段中的二硫键还原。
• COMPOSITIONS AND METHODS FOR ANTIBODY PRODUCTION
  申请人：Immunogen, Inc.

  公开号：EP3077522A1

  公开（公告）日：2016-10-12