4,6-Dinitrocyclohexa-2,4-dien-1-one

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 4,6-Dinitrocyclohexa-2,4-dien-1-one
• 英文别名: 4,6-dinitrocyclohexa-2,4-dien-1-one
• 化学式: C6H4N2O5
• 分子量: 184.11
• InChiKey: IGQDKAYMVPXCII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  109
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• METHODS OF TREATING NEUROENDOCRINE TUMORS USING WNT PATHWAY-BINDING AGENTS
  申请人：OncoMed Pharmaceuticals, Inc.

  公开号：EP2911691A1

  公开（公告）日：2015-09-02
• [EN] METHODS OF TREATING NEUROENDOCRINE TUMORS USING WNT PATHWAY-BINDING AGENTS<br/>[FR] MÉTHODES DE TRAITEMENT DE TUMEURS NEURO-ENDOCRINES À L'AIDE D'AGENTS LIANTS DE PARCOURS WNT
  申请人：ONCOMED PHARM INC

  公开号：WO2014066328A1

  公开（公告）日：2014-05-01

  Novel methods of treating neuroendocrine tumors are provided. In one embodiment, the method comprises administering to a subject in need thereof a therapeutically effective dose of a Wnt antagonist. In one embodiment, the Wnt antagonist is an anti-FZD antibody. In another embodiment, the Wnt antagonist is a soluble FZD receptor polypeptide. In a further embodiment, the Wnt antagonist is an anti-Wnt antibody.
• [EN] COMPOUNDS WITH ANTIMALARIAL ACTIVITY<br/>[FR] COMPOSÉS AYANT UNE ACTIVITÉ ANTIPALUDÉENNE
  申请人：UNIV PUERTO RICO

  公开号：WO2020209932A1

  公开（公告）日：2020-10-15

  Methods of inhibiting growth of a Plasmodium species, treating malaria, and inhibiting a glutathione S-transferase are provided. The methods include inhibiting growth of a Plasmodium species comprising contacting a Plasmodium species with a compound as disclosed herein. The methods also include treating malaria comprising administering a compound as disclosed herein to a human or animal patient, preferably a human patient, in need thereof. The methods further include inhibiting a glutathione S-transferase (GST) comprising contacting a GST with a compound as disclosed herein. Also provided are compounds for use in the disclosed methods.
• [EN] GLUFOSINATE ADDITIVE FOR IMPROVED WEED CONTROL<br/>[FR] ADDITIF DE GLUFOSINATE POUR UNE LUTTE AMÉLIORÉE CONTRE LES MAUVAISES HERBES
  申请人：UNIV ARKANSAS

  公开号：WO2021097418A1

  公开（公告）日：2021-05-20

  Disclosed herein is a herbicide and methods for the control of a grass or a broadleaf weed in a crop. The herbicide comprises an effective amount glufosinate, or a salt thereof, and an effective amount of a metabolic inhibitor.
• [EN] FACULTATIVE PROTEIN SELENYLATION FOR MODULATING METABOLISM<br/>[FR] SÉLÉNYLATION FACULTATIVE DE PROTÉINE POUR MODULER LE MÉTABOLISME
  申请人：DANA FARBER CANCER INST INC

  公开号：WO2021158502A1

  公开（公告）日：2021-08-12

  The present invention relates, in part, to methods for modulating a metabolic response in a subject by modulating facultative protein selenylation in the subject.