(2S)-2-[2-[[(S)-carboxy-(4-hydroxyphenyl)methyl]amino]ethylamino]-2-(4-hydroxyphenyl)acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-[2-[[(S)-carboxy-(4-hydroxyphenyl)methyl]amino]ethylamino]-2-(4-hydroxyphenyl)acetic acid
• 化学式: C₁₈H₂₀N₂O₆
• 分子量: 360.4
• InChiKey: ZDTGIHMXOYIRJY-HOTGVXAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  139
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• PROTEOGLYCAN SPECIFIC BRANCHED PEPTIDES
  申请人：Phi Pharma SA

  公开号：EP4015004A1

  公开（公告）日：2022-06-22

  The present invention relates to oligomeric compounds comprising at least two peptide moieties that bind specifically to proteoglycans, their payload conjugates and pharmaceutical compositions containing the same. Instant compounds, payload conjugates and pharmaceutical compositions are particularly useful in the treatment of cancer and in diagnostics.

  本发明涉及由至少两个能与蛋白多糖特异性结合的肽分子组成的低聚化合物、其有效载荷共轭物以及含有这些物质的药物组合物。即时化合物、有效载荷共轭物和药物组合物特别适用于癌症治疗和诊断。
• Nanoparticle immunoconjugates
  申请人：Memorial Sloan Kettering Cancer Center

  公开号：US10548989B2

  公开（公告）日：2020-02-04

  Disclosed herein are nanoparticle immunoconjugates useful for therapeutics and/or diagnostics. The immunoconjugates have diameter (e.g., average diameter) no greater than 20 nanometers (e.g., as measured by dynamic light scattering (DLS) in aqueous solution, e.g., saline solution). In certain embodiments, the conjugates are silica-based nanoparticles with single chain antibody fragments attached thereto.

  本文公开了用于治疗和/或诊断的纳米颗粒免疫共轭物。免疫共轭物的直径（如平均直径）不大于 20 纳米（如在水溶液（如生理盐水）中通过动态光散射（DLS）测量）。在某些实施方案中，共轭物是硅基纳米粒子，其上附有单链抗体片段。
• Systems and methods for determining optimum patient-specific antibody dose for tumor targeting
  申请人：Memorial Sloan Kettering Cancer Center

  公开号：US10806808B2

  公开（公告）日：2020-10-20

  The present disclosure describes a non-linear compartmental model using PET-derived data to predict, on a patient-specific basis, the optimal therapeutic dose of cargo carrying antibody (e.g., huA33) such as radiolabeled antibody, the antigen occupancy, residency times in normal and malignant tissues, and the cancer-to-normal tissue (e.g., colorectal cancer-to-normal colon tissue) therapeutic index. In addition, the non-linear compartmental model can be readily applied to the development of strategies such as multi-step targeting (MST) designed to further improve the therapeutic indices of RIT.

  本公开内容描述了一种非线性区室模型，该模型使用 PET 衍生数据，根据患者特异性预测携带抗体（如 huA33）（如放射性标记抗体）的货物的最佳治疗剂量、抗原占位、在正常组织和恶性组织中的驻留时间以及癌症对正常组织（如结直肠癌对正常结肠组织）的治疗指数。此外，非线性区室模型还可随时应用于多步靶向（MST）等策略的开发，旨在进一步提高 RIT 的治疗指数。
• METHODS AND COMPOSITIONS FOR ENZYME-MEDIATED SITE-SPECIFIC RADIOLABELING OF GLYCOPROTEINS
  申请人：Life Technologies Corporation

  公开号：EP2912459A2

  公开（公告）日：2015-09-02
• IMAGING OF TUMOR-ASSOCIATED MACROPHAGES
  申请人：Memorial Sloan-Kettering Cancer Center

  公开号：EP3285814A1

  公开（公告）日：2018-02-28