Acetic acid;ethoxyethane;heptane

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Acetic acid;ethoxyethane;heptane
• 英文别名: acetic acid;ethoxyethane;heptane
• 化学式: C13H30O3
• 分子量: 234.38
• InChiKey: DDLWQCLETCOLMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.11
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• VASCULAR CHOLESTEROL INHIBITORS AND USE THEREOF
  申请人：Iproteos S.L

  公开号：EP3736284A1

  公开（公告）日：2020-11-11

  The present invention relates to compounds having pharmacological activity in the treatment of vascular cholesterol accumulation, plasma low-density lipoproteins (LDL) abnormal aggregation and/or inhibition or reduction of the formation of VSMC foam cells, processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy and/or prophylaxis of conditions wherein decrease of vascular cholesterol accumulation, inhibition of LDL aggregation, inhibition or reduction of the formation of VSMC foam cells and/or prevention of aggregated LDL (agLDL) internalization is useful such as atherosclerosis, coronary artery disease, stroke, peripheral artery disease, angina pectoris, thrombosis, hyperlipidemia, hyperlipoproteinemia type II, familial hypercholesterolemia, familial combined hyperlipidemia, type II diabetes, hypothyroidism, Cushing's syndrome and obesity.

  本发明涉及在治疗血管胆固醇积聚、血浆低密度脂蛋白（LDL）异常聚集和/或抑制或减少VSMC泡沫细胞形成方面具有药理活性的化合物、制备它们的工艺、包含它们的药物组合物，以及它们在治疗和/或预防减少血管胆固醇积聚的疾病中的用途、如动脉粥样硬化、冠状动脉疾病、中风、外周动脉疾病、心绞痛、血栓形成、高脂血症、II 型高脂蛋白血症、家族性高胆固醇血症、家族性合并高脂血症、II 型糖尿病、甲状腺功能减退症、库欣综合征和肥胖症。
• EP2728005A1
  申请人：——

  公开号：EP2728005A1

  公开（公告）日：2014-05-07
• LRP1 AS KEY RECEPTOR FOR THE TRANSFER OF STERIFIED CHOLESTEROL FROM VERY-LOW-DENSITY LIPOPROTEINS (VLDL) TO ISCHAEMIC CARDIAC MUSCLE
  申请人：Consejo Superior De Investigaciones Científicas (CSIC)

  公开号：EP2728005B1

  公开（公告）日：2018-08-22
• PRODUCTION OF PUFAS IN PLANTS
  申请人：BASF Plant Science Company GmbH

  公开号：EP3218498A2

  公开（公告）日：2017-09-20
• STABILISING FATTY ACID COMPOSITIONS
  申请人：BASF PLANT SCIENCE COMPANY GMBH

  公开号：US20180291389A1

  公开（公告）日：2018-10-11

  Assay method, comprising providing a plant capable of expressing a delta-12 desaturase, wherein said delta-12 desaturase has at least 50% total amino acid sequence identity to at least one of the sequences SEQ ID NO. 328 to 336, and/or at least 59% total amino acid sequence similarity to at least one of the sequences SEQ ID NO. 328 to 336, and wherein the plant is also capable of expressing at least one or more enzymes of unsaturated fatty acid metabolism, of which enzymes at least one is capable of using linoleic acid as a substrate, and of which enzymes at least one is supposedly connected to a plant metabolic property, growing the plant, and measuring said plant metabolic property for said plant.