3-[1]anthryl-propan-1-ol | 110378-42-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 3-[1]anthryl-propan-1-ol
• 英文别名: 3-Anthracen-1-ylpropan-1-ol
• CAS: 110378-42-2
• 化学式: C₁₇H₁₆O
• 分子量: 236.313
• InChiKey: CQXDWEGZOWIMST-UHFFFAOYSA-N

物化性质

• 沸点：
  444.6±14.0 °C(Predicted)
• 密度：
  1.155±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-[1]anthryl-propan-1-ol 在 四氢呋喃 、 吡啶 、 氢氧化钾 、 氢氟酸 、 二乙二醇 作用下， 生成 6-甲基苯并[a]蒽
  参考文献：
  名称：

  Syntheses of 1'-Methyl- and 4'-Methyl-1,2-benzanthracenes¹

  摘要：

  DOI：

  10.1021/jo01100a007
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 3-[1]anthryl-propan-1-ol
  参考文献：
  名称：

  Syntheses of 1'-Methyl- and 4'-Methyl-1,2-benzanthracenes¹

  摘要：

  DOI：

  10.1021/jo01100a007

文献信息

• CHEMICAL CONSTRUCTS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1119529B1

  公开（公告）日：2003-09-17
• [EN] CHEMICAL CONSTRUCTS<br/>[FR] PRODUITS DE SYNTHESE CHIMIQUES
  申请人：GLAXO GROUP LTD

  公开号：WO2000020357A2

  公开（公告）日：2000-04-13

  The invention provides a chemical construct for use in solid phase synthesis comprising a solid support Q having linked thereto via a connecting group Y a substrate R; the connecting group Y having first and second cleavage sites which are orthogonally and selectively cleavable; the second cleavage site being selectively cleavable to release the substrate; and the first cleavage site being located at a position between the second cleavage site and the solid support and being selectively cleavable to release a fragment Fr comprising the substrate and at least a portion of the connecting group Y; characterised in that cleavage at the first cleavage site forms or introduces on the chemical fragment Fr at the first cleavage site a moiety comprising a sensitising group G (such as an amino group) which sensitises the chemical fragment Fr to instrumental, e.g. mass spectroscopic, analysis. Also provided are methods of analysis employing the constructs, as well as intermediate constructs.
• [EN] CHEMICAL CONSTRUCTS<br/>[FR] CONSTRUCTIONS CHIMIQUES
  申请人：GLAXO GROUP LTD

  公开号：WO2001025171A1

  公开（公告）日：2001-04-12

  A chemical construct for use in solid phase synthesis comprising a solid support Q having linked thereto via a connecting group Y a substrate R; the connecting group Y having first and second cleavage sites which are orthogonally and selectively cleavable; the second cleavage site being selectively cleavable to release the substrate; and the first cleavage site being located at a position between the second cleavage site and the solid support and being selectively cleavable to release a fragment Fru comprising the substrate and at least a portion of the connecting group Y, wherein the said portion contains a chromophore Cu which facilitates analysis of the fragment Fru by ultra violet, visible or fluorescence spectroscopy, the chromophore Cu having a principal log E¿max? value of at least 2.5 and wherein (i) the principal log Emax value is at least 1.5 times greater than the principal log Emax of the substrate R; or (ii) the chromophore C?u¿ has an absorption peak at a wavelength remote from absorptions due to the substrate R; and to methods of analysis of products of solid phase synthesis using the constructs.
• Syntheses of 1'-Methyl- and 4'-Methyl-1,2-benzanthracenes¹
  作者：MELVIN S. NEWMAN、SEI OTSUKA

  DOI：10.1021/jo01100a007

  日期：1958.6