2-[[2-[[2-(dimethylamino)acetyl]-(5-methoxy-2,3-dihydro-1H-indol-6-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[[2-[[2-(dimethylamino)acetyl]-(5-methoxy-2,3-dihydro-1H-indol-6-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide
• 化学式: C₂₇H₂₉FN₈O₃
• 分子量: 532.6
• InChiKey: BRJSDKGZZBUMLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  128
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• NOVEL FUSION MOLECULES AND USES THEREOF
  申请人：Foundation Medicine, Inc.

  公开号：EP2914622A2

  公开（公告）日：2015-09-09
• NOVEL TRANSLOCATIONS IN LUNG CANCER
  申请人：Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis

  公开号：EP3004380A2

  公开（公告）日：2016-04-13
• [EN] NOVEL FUSION MOLECULES AND USES THEREOF<br/>[FR] NOUVELLES MOLÉCULES DE FUSION ET LEURS UTILISATIONS
  申请人：FOUNDATION MEDICINE INC

  公开号：WO2014071419A2

  公开（公告）日：2014-05-08

  Novel fusion molecules and uses are disclosed.
• [EN] NOVEL TRANSLOCATIONS IN LUNG CANCER<br/>[FR] NOUVELLES TRANSLOCATIONS DANS LE CANCER DU POUMON
  申请人：STICHTING HET NL KANKER INST ANTONI VAN LEEUWENHOEK ZIEKENHUIS

  公开号：WO2014193229A2

  公开（公告）日：2014-12-04

  The invention relates to methods for determining the presence or absence of striatin-anaplastic lymphoma kinase (STRN-ALK) gene fusion and/or a Fibroblast Growth Factor Receptor 3 - transforming acidic coiled-coil containing protein 3 (FGFR3-TACC3) gene fusion in an individual, especially an individual suffering from lung cancer. The invention further relates to a method for diagnosing an individual as having adenocarcinoma, and to a method for treating said individual. The invention additionally relates to a method for diagnosing an individual as having squamous cell carcinoma, and to a method for treating said individual.
• [EN] METHODS OF TREATING PEDIATRIC CANCERS<br/>[FR] MÉTHODES DE TRAITEMENT DE CANCERS PÉDIATRIQUES
  申请人：FOUNDATION MEDICINE INC

  公开号：WO2015066452A2

  公开（公告）日：2015-05-07

  Methods and compositions for treating pediatric cancers are disclosed.