H-His-OH.H-Arg-OH.H-Cys-OH

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-His-OH.H-Arg-OH.H-Cys-OH
• 英文别名: (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid;(2R)-2-amino-3-sulfanylpropanoic acid
• 化学式: C15H30N8O6S
• 分子量: 450.5
• InChiKey: QLNPSCFFZRFSJB-KENMCFOLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.86
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  284
• 氢给体数：
  10
• 氢受体数：
  12

文献信息

• NANOCOMPLEX CONTAINING CATIONIC PEPTIDE FOR BIOMOLECULE DELIVERY
  申请人：Council of Scientific and Industrial Research

  公开号：EP2916874A1

  公开（公告）日：2015-09-16
• IN VITRO AND IN VIVO INTRACELLULAR DELIVERY OF SIRNA VIA SELF-ASSEMBLED NANOPIECES
  申请人：Rhode Island Hospital

  公开号：US20210023117A1

  公开（公告）日：2021-01-28

  The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.
• US9572893B2
  申请人：——

  公开号：US9572893B2

  公开（公告）日：2017-02-21
• [EN] NANOCOMPLEX CONTAINING CATIONIC PEPTIDE FOR BIOMOLECULE DELIVERY<br/>[FR] NANOCOMPLEXE CONTENANT UN PEPTIDE CATIONIQUE POUR L'ADMINISTRATION D'UNE BIOMOLÉCULE
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2014072999A1

  公开（公告）日：2014-05-15

  The present invention relates to developing an optimally efficient arginine-histidine-cysteine based peptide comprising nanocomplex that can deliver biomolecules across varied cell lines without any oxidative procedure through formation of monodisperse nanoparticles with sizes ranging between 50 and 110 nm.
• [EN] IN VITRO AND IN VIVO INTRACELLULAR DELIVERY OF SIRNA VIA SELF-ASSEMBLED NANOPIECES<br/>[FR] ADMINISTRATION INTRACELLULAIRE IN VITRO ET IN VIVO D'ARNSI PAR L'INTERMÉDIAIRE DE NANO-PIÈCES AUTO-ASSEMBLÉES
  申请人：RHODE ISLAND HOSPTIAL

  公开号：WO2019191151A1

  公开（公告）日：2019-10-03

  The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.