(4E,5Z)-6-ethoxy-5-(ethoxymethyl)-4-ethylidene-7-methylocta-5,7-dien-3-ol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (4E,5Z)-6-ethoxy-5-(ethoxymethyl)-4-ethylidene-7-methylocta-5,7-dien-3-ol
• 化学式: C₁₆H₂₈O₃
• 分子量: 268.39
• InChiKey: REHDSRKXZWQSLI-UIOBQIQYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SUBSTITUTED PYRIDOXINE-LACTAM CARBOXYLATE SALTS
  申请人：Yamin Rina

  公开号：US20110294859A1

  公开（公告）日：2011-12-01

  The present invention provides salt adducts comprising at least one positively charged moiety being a pyridoxine or a derivative thereof and at least one carboxylated 5- to 7-membered lactam ring, optionally additionally substituted, methods of their preparation, and pharmaceutical compositions and medicaments comprising them. Salt adducts of the invention and compositions comprising them may be used to in the treatment of diseases or disorders associated with or inflicted by alcohol consumption.

  本发明提供了盐加合物，其中至少包含一种带有正电荷的基团，为吡ridoxine或其衍生物，以及至少一种羧化的5-到7-成员内酰胺环，可选择性地另外取代，以及其制备方法，以及包含它们的药物组合物和药物。本发明的盐加合物和包含它们的组合物可用于治疗与酒精消费相关或由酒精消费引起的疾病或疾病。
• METHOD FOR THE TREATMENT, ALLEVIATION OF SYMPTOMS OF, RELIEVING, IMPROVING AND PREVENTING A COGNITIVE DISEASE, DISORDER OR CONDITION
  申请人：Alcobra Ltd.

  公开号：US20160199362A1

  公开（公告）日：2016-07-14

  The present invention provides uses of a salt adduct comprising at least one positively charged moiety being a pyridoxine or a derivative thereof and at least one carboxylated 5- to 7-membered lactam ring, optionally additionally substituted, for the preparation of a medicament for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition in a subject. Additionally, the invention provides use of said salt adducts for the preparation of medicaments for the improvement of cognitive functions in a healthy subject.
• US8710067B2
  申请人：——

  公开号：US8710067B2

  公开（公告）日：2014-04-29