propan-2-yl (2S)-2-[[methyl-(2-oxo-2-propan-2-yloxyethoxy)phosphoryl]amino]propanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: propan-2-yl (2S)-2-[[methyl-(2-oxo-2-propan-2-yloxyethoxy)phosphoryl]amino]propanoate
• 化学式: C₁₂H₂₄NO₆P
• 分子量: 309.3
• InChiKey: YQJGQJWHKPWTDX-FVINQWEUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  90.9
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] 2'-DISUBSTITUTED SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES<br/>[FR] DÉRIVÉS NUCLÉOSIDES SUBSTITUÉS 2'-DISUBSTITUÉS ET LEURS PROCÉDÉS D'UTILISATION POUR LE TRAITEMENT DE MALADIES VIRALES
  申请人：MERCK SHARP & DOHME

  公开号：WO2014059902A1

  公开（公告）日：2014-04-24

  2'-disubstituted substituted nucleoside derivatives of formula (I) and pharmaceutically acceptable salts thereof are disclosed:(1), wherein A is N3 or NH2 and X, Y, R1, R2, R3, R4,R5 and R18 are as defined herein. Compositions comprising at least one 2'-disubstituted nucleoside derivative, and methods of using the 2'-disubstituted nucleoside derivatives for treating or preventing HCV infection in a patient are disclosed.

  本文披露了公式(I)的2'-二取代核苷衍生物及其药学上可接受的盐：(1)，其中A为N3或NH2，X、Y、R1、R2、R3、R4、R5和R18如本文所定义。本文还披露了包含至少一种2'-二取代核苷衍生物的组合物，以及使用这些2'-二取代核苷衍生物治疗或预防患者HCV感染的方法。
• 2'-CYANO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
  申请人：Girijavallabhan Vinay

  公开号：US20150274739A1

  公开（公告）日：2015-10-01

  Compounds of Formula (I) are disclosed, wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 18 are defined herein. The compounds encompassed by Formula (I) include compounds which are HCV NS5B inhibitors and other compounds which can be metabolized in vivo to HCV NS5B inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HCV and the prophylaxis, treatment, or delay in the onset of disease caused by HCV. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
• 2'-DISUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20160045526A1

  公开（公告）日：2016-02-18

  2′-disubstituted substituted nucleoside derivatives of formula (I) and pharmaceutically acceptable salts thereof are disclosed: (1), wherein A is N 3 or NH 2 and X, Y, R 1 , R 2 , R 3 , R 4 , R 5 and R 18 are as defined herein. Compositions comprising at least one 2′-disubstituted nucleoside derivative, and methods of using the 2′-disubstituted nucleoside derivatives for treating or preventing HCV infection in a patient are disclosed.
• US9242988B2
  申请人：——

  公开号：US9242988B2

  公开（公告）日：2016-01-26
• US9457039B2
  申请人：——

  公开号：US9457039B2

  公开（公告）日：2016-10-04