(2S)-4-hydroxy-4-methyl-2-(methylamino)pentanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-4-hydroxy-4-methyl-2-(methylamino)pentanamide
• 化学式: C₇H₁₆N₂O₂
• 分子量: 160.21
• InChiKey: POQOCNJTSIFKNE-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  75.4
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Cyclosporin Analogs
  申请人：Allergan, Inc.

  公开号：US20160022765A1

  公开（公告）日：2016-01-28

  Disclosed herein are novel analogs of cyclosporin, pharmaceutical compositions containing them, and methods for their use in the treatment of dry eye and other conditions.

  本文披露了环孢霉素的新型类似物，包含它们的药物组合物，以及它们在治疗干眼症和其他疾病中的应用方法。
• MACROCYCLES
  申请人：Scynexis, Inc.

  公开号：US20140212381A1

  公开（公告）日：2014-07-31

  Cyclosporin derivatives, methods of manufacturing the cyclosporin derivatives and methods for treating subjects infected with certain viruses, including hepatitis virus or HIV by administering the cyclosporin derivatives are described.
• ANTIVIRAL MACROCYCLES
  申请人：Scynexis, Inc.

  公开号：US20140213508A1

  公开（公告）日：2014-07-31

  Cyclosporin derivatives, methods of manufacturing the cyclosporin derivatives and methods for treating subjects infected with certain viruses, including hepatitis virus or HIV by administering the cyclosporin derivatives are described.
• US9561259B2
  申请人：——

  公开号：US9561259B2

  公开（公告）日：2017-02-07
• [EN] NEW ANTIVIRAL MACROCYCLES<br/>[FR] NOUVEAUX MACROCYCLES ANTIVIRAUX
  申请人：SCYNEXIS INC

  公开号：WO2014063147A1

  公开（公告）日：2014-04-24

  Cyclosporin derivatives, methods of manufacturing the cyclosporin derivatives and methods for treating subjects infected with certain viruses, including hepatitis virus or HIV by administering the cyclosporin derivatives are described.