2-(3,3-Dihydroxypropyl)octanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-(3,3-Dihydroxypropyl)octanoic acid
• 英文别名: 2-(3,3-dihydroxypropyl)octanoic acid
• 化学式: C₁₁H₂₂O₄
• 分子量: 218.29
• InChiKey: LEUIJOOFPOSCMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• DELIVERY OF BIOLOGICALLY-ACTIVE AGENTS USING VOLATILE, HYDROPHOBIC SOLVENTS
  申请人：Rochal Industries, LLC

  公开号：EP2916820A1

  公开（公告）日：2015-09-16
• COMPOSITIONS AND KITS FOR ENZYMATIC DEBRIDEMENT AND METHODS OF USING THE SAME
  申请人：Rochal Industries, LLC

  公开号：EP3204037A1

  公开（公告）日：2017-08-16
• [EN] DELIVERY OF BIOLOGICALLY-ACTIVE AGENTS USING VOLATILE, HYDROPHOBIC SOLVENTS<br/>[FR] ADMINISTRATION D'AGENTS BIOLOGIQUEMENT ACTIFS À L'AIDE DE SOLVANTS HYDROPHOBES, VOLATILS
  申请人：ROCHAL IND LLP

  公开号：WO2014074289A1

  公开（公告）日：2014-05-15

  A composition and method adapted for delivery of hydrophilic, biologically-active agents are disclosed. The composition can include a reverse microemulsion formed from at least one hydrophilic, biologically-active agent solubilized by a hydrophobic reverse emulsion surfactant in a non-stinging, volatile, hydrophobic solvent. The non-stinging, volatile, hydrophobic solvent is selected from the group consisting of volatile linear and cyclic siloxanes, volatile linear, branched, and cyclic alkanes, volatile fluorocarbons and chlorofluorocarbons, liquid carbon dioxide under pressure, and combinations thereof. The reverse microemulsion can be an optically clear solution.
• [EN] COMPOSITIONS AND KITS FOR ENZYMATIC DEBRIDEMENT AND METHODS OF USING THE SAME<br/>[FR] COMPOSITIONS ET KITS POUR LE DÉBRIDEMENT ENZYMATIQUE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ROCHAL IND LLC

  公开号：WO2016057788A1

  公开（公告）日：2016-04-14

  A debridement enzyme for necrotic tissue is described that is not dependent upon proteolytic enzymatic activity but instead utilizes the amylase family of enzymes. The amylases (α-, β-, γ-amylase) are noted for the cleavage of the a-glycosidic bonds of polysaccharides, yielding lower molecular weight carbohydrate/sugar fragments. It has now been found that a-amylase is effective in the debridement of devitalized tissue.