Methyl 5-cyano-5-[4-(difluoromethoxy)phenyl]-2-oxocyclohexane-1-carboxylate;2-oxabicyclo[2.1.0]pentane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Methyl 5-cyano-5-[4-(difluoromethoxy)phenyl]-2-oxocyclohexane-1-carboxylate;2-oxabicyclo[2.1.0]pentane
• 英文别名: methyl 5-cyano-5-[4-(difluoromethoxy)phenyl]-2-oxocyclohexane-1-carboxylate;2-oxabicyclo[2.1.0]pentane
• 化学式: C20H21F2NO5
• 分子量: 393.4
• InChiKey: SYUQIMQUNIFJDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.0
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  85.6
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Pharmaceutical compositions containing a PDE4 inhibitor and a PI3 delta or dual PI3 delta-gamma kinase inhibitor
  申请人：Rhizen Pharmaceuticals SA

  公开号：US10058539B2

  公开（公告）日：2018-08-28

  This present invention relates to a method of treating a autoimmune, respiratory and/or inflammatory disease or condition (e.g., psoriasis, rheumatoid arthritis, asthma, COPD). The method comprises administering a PI3K Delta inhibitor or a dual PI3K Delta-Gamma inhibitor and a PDE4 inhibitor. The present invention also relates to pharmaceutical compositions containing a PI3K Delta or dual PI3K Delta-Gamma inhibitor and a PDE4 inhibitor.

  本发明涉及一种治疗自身免疫性、呼吸道和/或炎症性疾病或病症（如银屑病、类风湿性关节炎、哮喘、慢性阻塞性肺病）的方法。该方法包括给药 PI3K Delta 抑制剂或双重 PI3K Delta-Gamma 抑制剂和 PDE4 抑制剂。本发明还涉及含有PI3K Delta或双重PI3K Delta-Gamma抑制剂和PDE4抑制剂的药物组合物。
• PHARMACEUTICAL COMPOSITIONS CONTAINING A PDE4 INHIBITOR AND A PI3 DELTA OR DUAL PI3 DELTA-GAMMA KINASE INHIBITOR
  申请人：Rhizen Pharmaceuticals S.A.

  公开号：EP2916868A1

  公开（公告）日：2015-09-16
• PHARMACEUTICAL COMPOSITIONS CONTAINING A PDE4 INHIBITOR AND A P13 DELTA OR DUAL P13 DELTA-GAMMA KINASE INHIBITOR
  申请人：Rhizen Pharmaceuticals SA

  公开号：US20200237735A1

  公开（公告）日：2020-07-30

  This present invention relates to a method of treating a autoimmune, respiratory and/or inflammatory disease or condition (e.g., psoriasis, rheumatoid arthritis, asthma, COPD). The method comprises administering a PI3K Delta inhibitor or a dual PI3K Delta-Gamma inhibitor and a PDE4 inhibitor. The present invention also relates to pharmaceutical compositions containing a PI3K Delta or dual PI3K Delta-Gamma inhibitor and a PDE4 inhibitor.
• US9737521B2
  申请人：——

  公开号：US9737521B2

  公开（公告）日：2017-08-22
• [EN] PHARMACEUTICAL COMPOSITIONS CONTAINING A PDE4 INHIBITOR AND A PI3 DELTA OR DUAL PI3 DELTA-GAMMA KINASE INHIBITOR<br/>[FR] COMPOSITIONS PHARMACEUTIQUES CONTENANT UN INHIBITEUR DE PDE4 ET UN INHIBITEUR DE PI3 KINASE DELTA OU UN DOUBLE INHIBITEUR DE PI3 KINASE DELTA ET GAMMA
  申请人：RHIZEN PHARMACEUTICALS SA

  公开号：WO2014072937A1

  公开（公告）日：2014-05-15

  This present invention relates to a method of treating a autoimmune, respiratory and/or inflammatory disease or condition (e.g., psoriasis, rheumatoid arthritis, asthma, COPD). The method comprises administering a PI3K Delta inhibitor or a dual PI3K Delta- Gamma inhibitor and a PDE4 inhibitor. The present invention also relates to pharmaceutical compositions containing a PI3K Delta or dual PI3K Delta-Gamma inhibitor and a PDE4 inhibitor.