(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid;2-hydroxybenzamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid;2-hydroxybenzamide
• 化学式: C20H25Cl2N3O4
• 分子量: 442.3
• InChiKey: FIJBLZCUFUZFNN-YDALLXLXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.42
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Method for regulating retinal endothelial cell viability
  申请人：The University of Tennessee Research Foundation

  公开号：US10010516B2

  公开（公告）日：2018-07-03

  Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a quinic acid analog. The method may be applied to prevent, treat or cure pathological conditions of retinal endothelial cells associated with radiation retinopathy, diabetic retinopathy and chemotherapy for retinoblastoma.

  本文提供了一种通过向哺乳动物施用治疗有效量的奎宁酸类似物来调节哺乳动物视网膜内皮细胞活力的方法。该方法可用于预防、治疗或治愈与辐射视网膜病变、糖尿病视网膜病变和视网膜母细胞瘤化疗相关的视网膜内皮细胞病变。
• METHOD FOR REGULATING RETINAL ENDOTHELIAL CELL VIABILITY
  申请人：of Tennessee Research Foundation The University

  公开号：US20170143652A1

  公开（公告）日：2017-05-25

  Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a quinic acid analog. The method may be applied to prevent, treat or cure pathological conditions of retinal endothelial cells associated with radiation retinopathy, diabetic retinopathy and chemotherapy for retinoblastoma.
• US9566255B2
  申请人：——

  公开号：US9566255B2

  公开（公告）日：2017-02-14
• [EN] METHOD FOR REGULATING RETINAL ENDOTHELIAL CELL VIABILITY<br/>[FR] MÉTHODE DE RÉGULATION DE LA VIABILITÉ DE CELLULES ENDOTHÉLIALES RÉTINIENNES
  申请人：UNIV TENNESSEE RES FOUNDATION

  公开号：WO2014074734A1

  公开（公告）日：2014-05-15

  Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a quinic acid analog. The method may be applied to prevent, treat or cure pathological conditions of retinal endothelial cells associated with radiation retinopathy, diabetic retinopathy and chemotherapy for retinoblastoma.