2-[3-[[(2R)-2-hydroxy-3,3-dimethylpentanoyl]amino]propanoylamino]ethylsulfanyl (3Z,6Z,9Z,12Z,15Z,18Z)-henicosa-3,6,9,12,15,18-hexaenoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-[3-[[(2R)-2-hydroxy-3,3-dimethylpentanoyl]amino]propanoylamino]ethylsulfanyl (3Z,6Z,9Z,12Z,15Z,18Z)-henicosa-3,6,9,12,15,18-hexaenoate
• 化学式: C₃₃H₅₂N₂O₅S
• 分子量: 588.8
• InChiKey: PEZXPIZESKKPKF-FIFCEARLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  41
• 可旋转键数：
  24
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  130
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROLOGICAL AND NEURODEGENERATIVE DISEASES<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE MALADIES NEUROLOGIQUES ET NEURODÉGÉNÉRATIVES
  申请人：KANDULA MAHESH

  公开号：WO2014060925A2

  公开（公告）日：2014-04-24

  The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of neurological diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of seizures, Huntington's disease, spasms, mental diseases, mental disorders, schizophrenia, depression, bipolar disorder, Alzheimer's disease, anxiety, ADHD, dementia, mood disorders, PTSD, sleeplessness, epilepsy, migraine, psychosis, OCD, autism, anxiety disorders, dementia, mania, cognitive disorders.
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF PAIN AND NEUROLOGICAL DISEASES<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE LA DOULEUR ET DE MALADIES NEUROLOGIQUES
  申请人：KANDULA MAHESH

  公开号：WO2014068459A2

  公开（公告）日：2014-05-08

  The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of pain and neurological diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of partial-onset seizures, diabetic neuropathic pain, back pain and other orthopaedic uses, migraines, oncology, postoperative care, gynaecology, Creutzfeld- Jakob disease, multiple sclerosis, Batten disease, fibromyalgia, Alzheimer's disease, and multiple sclerosis.
• [EN] COMPOSITIONS AND METHODS OF FOR THE TREATMENT OF MULTIPLE SCLEROSIS AND NEURODEGENERATIVE DISEASES<br/>[FR] COMPOSITIONS ET MÉTHODES POUR LE TRAITEMENT DE LA SCLÉROSE EN PLAQUES ET DE MALADIES NEURODÉGÉNÉRATIVES
  申请人：KANDULA MAHESH

  公开号：WO2014060942A2

  公开（公告）日：2014-04-24

  The disclosures herein provide aminoacid derivatives containing therapeutic copolymer of formula I or its pharmaceutical acceptable salts, as well as polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. These salts may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for oral administration, intravenous, subdermal, transdermal administration, or injection. Such compositions aminoacid derivatives containing therapeutic copolymer may be used to treatment of multiple sclerosis and neurodegenerative diseases or its associated complications.
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROLOGIC DISEASES AND NEUROLOGICAL DISORDERS<br/>[FR] COMPOSITIONS ET MÉTHODES POUR LE TRAITEMENT DE MALADIES NEUROLOGIQUES ET DE TROUBLES NEUROLOGIQUES
  申请人：KANDULA MAHESH

  公开号：WO2014068460A2

  公开（公告）日：2014-05-08

  The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing neurologic diseases and neurological disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of partial-onset seizures, infantile spasm, mixed seizure types of Lennox-Gastaut syndrome, myoclonic, generalized tonic clonic seizure, epilepsy, Parkinson's, obesity, migraines and bipolar depression.
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF ACUTE INFLAMMATION<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT D'UNE INFLAMMATION AIGUË
  申请人：KANDULA MAHESH

  公开号：WO2014068461A2

  公开（公告）日：2014-05-08

  The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of acute inflammation may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of neuropathy, polyps and precancerous lesions in the colon, especially in association with familial adenomatous polyposis, cancer, Alzheimer's disease and pain.