deamino-hPhe-His-D-Phe-Arg-Trp-Gly-Lys(Me)-al

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: deamino-hPhe-His-D-Phe-Arg-Trp-Gly-Lys(Me)-al
• 英文别名: (2S)-5-(diaminomethylideneamino)-2-[[(2R)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-(4-phenylbutanoylamino)propanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-3-(1H-indol-3-yl)-1-[[2-[[(2S)-6-(methylamino)-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]pentanamide
• 化学式: C₅₁H₆₇N₁₃O₇
• 分子量: 974.2
• InChiKey: XZFDJLBBZGVTIM-FFYCFEHJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  71
• 可旋转键数：
  31
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  313
• 氢给体数：
  11
• 氢受体数：
  10

文献信息

• MELANOCORTIN 1 RECEPTOR LIGANDS AND METHODS OF USE
  申请人：Gillies Robert J.

  公开号：US20140112873A1

  公开（公告）日：2014-04-24

  The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.
• MELANOTROPIN LIGANDS FOR SKIN CARE
  申请人：THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

  公开号：US20150284431A1

  公开（公告）日：2015-10-08

  A MC1R peptide ligand-elastic vesicle complex for preventing skin maladies. The MC1R peptide ligand is modified by coupling the melanocortin 1 receptor (MC1R) ligand to a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, elastic vesicles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The MC1R peptide ligand-elastic vesicle complex is prepared as a patch or viscous emulsion that can be applied to human skin.
• US9290539B2
  申请人：——

  公开号：US9290539B2

  公开（公告）日：2016-03-22
• US9441013B2
  申请人：——

  公开号：US9441013B2

  公开（公告）日：2016-09-13
• US9539301B2
  申请人：——

  公开号：US9539301B2

  公开（公告）日：2017-01-10